Evidence map›Paper›PMID 30413654›Full record

ArticleThe Plant cell2018

Integrating Coexpression Networks with GWAS to Prioritize Causal Genes in Maize.

Robert J Schaefer, Jean-Michel Michno, Joseph Jeffers, Owen Hoekenga, Brian Dilkes, Ivan Baxter, Chad L Myers

Open access · bronzeAbstract read
In one paragraph

Article in The Plant cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 187 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Robert J SchaeferBiomedical Informatics and Computational Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0001-9455-5805
Jean-Michel MichnoBiomedical Informatics and Computational Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0003-3723-2246
Joseph JeffersDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0003-3706-5839
Owen HoekengaCayuga Genetics Consulting Group LLC, Ithaca, New York 14850.ORCID 0000-0003-4427-2000
Brian DilkesDepartment of Biochemistry, Purdue University, West Lafayette, Indiana 47907.ORCID 0000-0003-2799-954X
Ivan BaxterDonald Danforth Plant Science Center, St. Louis, Missouri 63132 ibaxter@danforthcenter.org chadm@umn.edu.ORCID 0000-0001-6680-1722
Chad L MyersDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota 55455 ibaxter@danforthcenter.org chadm@umn.edu.ORCID 0000-0002-1026-5972
University of Minnesota · USAgricultural Research Service · USIthaca College · USPurdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified loci linked to hundreds of traits in many different species. Yet, because linkage equilibrium implicates a broad region surrounding each identified locus, the causal genes often remain unknown. This problem is especially pronounced in nonhuman, nonmodel species, where functional annotations are sparse and there is frequently little information available for prioritizing candidate genes. We developed a computational approach, Camoco, that integrates loci identified by GWAS with functional information derived from gene coexpression networks. Using Camoco, we prioritized candidate genes from a large-scale GWAS examining the accumulation of 17 different elements in maize (

Indexed as

Genome-Wide Association StudyLinkage DisequilibriumSoftwareZea mays

Identifiers

PMID30413654
PMCPMC6354270
OpenAlexW2951582270

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.