ArticleTranslational psychiatry2018
Elevated allostatic load early in the course of schizophrenia.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Allostatic load index across the psychosis spectrum: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research.International journal of environmental research and public health · 2022Pooled it
- The past and future of integrated biopsychosocial whole-health perspectives in psychiatric rehabilitation.Psychiatric rehabilitation journal · 2026Review
- Integrating allostasis and emerging technologies to study complex diseases.Communications biology · 2025Review
- Stress-related multisystem dysregulation during adolescence predicts mental health symptoms in young adulthood.Psychological medicine · 2025Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.American journal of epidemiology · 2025Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia.Trends in neurosciences · 2022Review
- Allostatic-Interoceptive Overload in Frontotemporal Dementia.Biological psychiatry · 2022Article
- Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations.Diseases (Basel, Switzerland) · 2022Article
- Acute and Lifetime Stress and Psychotic Illness: The Roles of Reward and Salience Networks.Journal of psychiatry and brain science · 2022Article
- Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia.Schizophrenia bulletin · 2021Article
- Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia.NPJ schizophrenia · 2020Article
- Choroid Plexus Enlargement and Allostatic Load in Schizophrenia.Schizophrenia bulletin · 2020Article
- Schizophrenia Mortality: Barriers to Progress.The Psychiatric quarterly · 2019Review
- Stress, Allostatic Load, and Psychosis: One Step Forward in Research But Where to Go Next?Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Stress plays a significant role in schizophrenia from disease onset to exacerbation of psychotic symptoms. Allostatic load (AL) is a measure of cumulative stress to the organism. This study is an extension of our previous work on AL and its relationship to brain structures. Here, we further determined whether elevated AL is a function of illness chronicity, or if it is already present early in the course of schizophrenia. AL was compared in schizophrenia patients early in the illness (within 5 years of disease onset), patients with chronic schizophrenia (more than 5 years of illness), and two groups of healthy controls that were age-and sex-matched to the two patient groups. This work is presented with an expanded sample and includes about two-thirds of the participants who were previously reported. We found that patients with early psychosis had significantly elevated AL score compared with their age-matched controls (p = 0.005). Chronic course patients also had elevated AL compared with age-matched controls (p = 0.003). Immune and stress hormone AL subcomponents were nominally higher in early-stage patients compared with controls (p = 0.005 and 0.04, respectively). Greater AL was also associated with more severe positive psychotic symptoms in early-stage patients (r = 0.54, p = 0.01). Elevated levels of allostatic load are already present in the early years of the schizophrenia illness, particularly in patients with more severe psychotic symptoms. AL may be a useful evaluation for the need of early intervention on psychosomatic comorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.