Evidence map›Paper›PMID 30427276›Full record

ReviewPhysiological reviews2019

Building and Regenerating the Lung Cell by Cell.

Jeffrey A Whitsett, Tanya V Kalin, Yan Xu, Vladimir V Kalinichenko

Abstract readReview
In one paragraph

Review in Physiological reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 209 citations in OpenAlex.

  1. Trial
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  8. The transcriptional landscape of developing human trisomy 21 lungs.American journal of respiratory cell and molecular biology · 2026
    Article
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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeffrey A WhitsettPerinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati, Ohio.
Tanya V KalinPerinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati, Ohio.
Yan XuPerinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati, Ohio.
Vladimir V KalinichenkoPerinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati, Ohio.
Cincinnati Children's Hospital Medical Center · US

Funding

Molecular Atlas of Lung Development - Data Coordinating CenterU01HL122638 · NHLBI · DUKE UNIVERSITY · PI CLARK, ROBERT F, PALMER, SCOTT M · 2014 to 2018
$7.5M
Fox Transcription Factors in Development of Pulmonary CapillariesR01HL084151 · NHLBI · UNIVERSITY OF CHICAGO · PI KALINICHENKO, VLADIMIR · 2006 to 2018
$4.9M
Transcriptional Regulation of Endothelial Cells after Neonatal Lung InjuryR01HL141174 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2018 to 2026
$4.7M
LungMap Phase II - Building a multidimensional map of developing human lungU01HL148856 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A, XU, YAN · 2019 to 2023
$4.5M
"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
Role of EMC3/TMEM111 in Alveolar Epithelial Cell FunctionR01HL136722 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LIN, XINHUA, WHITSETT, JEFFREY A · 2017 to 2020
$2.1M
Transcriptional regulation of goblet cell metaplasiaR01HL123490 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KALINICHENKO, VLADIMIR · 2014 to 2017
$1.6M
Targeting Foxm1 in pulmonary fibrosisR01HL132849 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KALIN, TANYA · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL084151NHLBI NIH HHS R01 HL123490NHLBI NIH HHS R01 HL132849NHLBI NIH HHS R01 HL136722NHLBI NIH HHS R01 HL141174NHLBI NIH HHS U01 HL122638NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01 HL148856
6 · The paper itself

Abstract

The unique architecture of the mammalian lung is required for adaptation to air breathing at birth and thereafter. Understanding the cellular and molecular mechanisms controlling its morphogenesis provides the framework for understanding the pathogenesis of acute and chronic lung diseases. Recent single-cell RNA sequencing data and high-resolution imaging identify the remarkable heterogeneity of pulmonary cell types and provides cell selective gene expression underlying lung development. We will address fundamental issues related to the diversity of pulmonary cells, to the formation and function of the mammalian lung, and will review recent advances regarding the cellular and molecular pathways involved in lung organogenesis. What cells form the lung in the early embryo? How are cell proliferation, migration, and differentiation regulated during lung morphogenesis? How do cells interact during lung formation and repair? How do signaling and transcriptional programs determine cell-cell interactions necessary for lung morphogenesis and function?

Indexed as

AnimalsCell DifferentiationCell ProliferationEmbryonic DevelopmentGene Expression Regulation, DevelopmentalHumansLungMorphogenesis

Identifiers

PMID30427276
PMCPMC6442926
OpenAlexW2901127498

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.