Evidence map›Paper›PMID 30427760›Full record

ArticleMolecular biology of the cell2019

Phosphatidylinositol 3,5-bisphosphate regulates the transition between trans-SNARE complex formation and vacuole membrane fusion.

Gregory E Miner, Katherine D Sullivan, Annie Guo, Brandon C Jones, Logan R Hurst, Ez C Ellis, Matthew L Starr, Rutilio A Fratti

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Roles of PIKfyve in multiple cellular pathways.Current opinion in cell biology · 2022
    Review
  6. Article
  7. Phosphatidylinositol 3,5-bisphosphate regulates CaTraffic (Copenhagen, Denmark) · 2020
    Article
  8. Review
  9. Article
  10. Review
  11. Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission.Frontiers in cell and developmental biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gregory E MinerDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Katherine D SullivanDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Annie GuoDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Brandon C JonesDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Logan R HurstDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Ez C EllisDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Matthew L StarrDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Rutilio A FrattiDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
University of Illinois Urbana-Champaign · US

Funding

Allosteric Regulation of SNAREs and the Rab GEF Mon1 by PhosphoinositidesR01GM101132 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FRATTI, RUTILIO A · 2012 to 2016
$1.4M
National Science Foundation MCB 18-18310NIGMS NIH HHS R01 GM101132
6 · The paper itself

Abstract

Phosphoinositides (PIs) regulate a myriad of cellular functions including membrane fusion, as exemplified by the yeast vacuole, which uses various PIs at different stages of fusion. In light of this, the effect of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P

Indexed as

Membrane FusionLipidsMolecular Docking SimulationMutationPhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSNARE ProteinsVacuolesFAB1 protein, S cerevisiaeLipidsphosphatidylinositol 3,5-diphosphatePhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiae ProteinsSNARE Proteins

Identifiers

PMID30427760
PMCPMC6589561
OpenAlexW2901487262

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.