Evidence map›Paper›PMID 30442723›Full record

ArticleHaematologica2019

EXPAND, a dose-finding study of ruxolitinib in patients with myelofibrosis and low platelet counts: 48-week follow-up analysis.

Alessandro M Vannucchi, Peter A W Te Boekhorst, Claire N Harrison, Guangsheng He, Marianna Caramella, Dietger Niederwieser, Françoise Boyer-Perrard, Minghui Duan, Nathalie Francillard, Betty Molloy and 2 more

Abstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. JAK Inhibitors for Myelofibrosis: Strengths and Limitations.Current hematologic malignancy reports · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Polycythemia Vera: Barriers to and Strategies for Optimal Management.Blood and lymphatic cancer : targets and therapy · 2023
    Review
  16. New approaches to tackle cytopenic myelofibrosis.Hematology. American Society of Hematology. Education Program · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessandro M VannucchiCenter for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero Universitaria Careggi, University of Florence, Italy amvannucchi@unifi.it.
Peter A W Te BoekhorstErasmus Medical Center, Rotterdam, the Netherlands.
Claire N HarrisonGuy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.
Guangsheng HeNo. 1 Hospital of Nanjing Medical University, China.
Marianna CaramellaASST Grande Ospedale Metropolitano, Milano, Italy.
Dietger NiederwieserDepartment of Hematology and Medical Oncology, University of Leipzig, Germany.
Françoise Boyer-PerrardCentre Hospitalier Universitaire d'Angers, France.
Minghui DuanPeking Union Medical College Hospital, Beijing, China.
Nathalie FrancillardNovartis Pharma S.A.S, Rueil Malmaison, France.
Betty MolloyNovartis AG, Basel, Switzerland.
Monika WroclawskaNovartis AG, Basel, Switzerland.
Heinz GisslingerDepartment of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

EEXPAND (phase Ib, dose-finding study) evaluated the starting dose of ruxolitinib in patients with myelofibrosis with baseline platelet counts of 50-99×10

Indexed as

AdolescentAdultAgedAged, 80 and overDrug Administration ScheduleFemaleFollow-Up StudiesHumansMaleMaximum Tolerated DoseMiddle AgedNitrilesPrimary MyelofibrosisPrognosisProtein Kinase InhibitorsPyrazolesNitrilesProtein Kinase InhibitorsPyrazolesPyrimidinesruxolitinib

Identifiers

PMID30442723
PMCPMC6518918

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.