Evidence mapPaperPMID 30444720Full record

ReviewEndocrine-related cancer2019

Peroxisome proliferator-activated receptor gamma and BRCA1.

Priscilla A Furth

Open access · bronzeAbstract readReview
In one paragraph

Review in Endocrine-related cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Priscilla A FurthDepartments of Oncology and Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA.
Georgetown University Medical Center · US

Funding

Tissue Culture and Biobanking Shared ResourceP30CA051008 · GEORGETOWN UNIVERSITY · 1990 to 2025
$20.3M
Progression and regression of mammary preneoplasiaR01CA112176 · GEORGETOWN UNIVERSITY · 2005 to 2005
$286k
NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA112176
6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor gamma agonists have been proposed as breast cancer preventives. Individuals who carry a mutated copy of BRCA1, DNA repair-associated gene, are at increased risk for development of breast cancer. Published data in the field suggest there could be interactions between peroxisome proliferator-activated receptor gamma and BRCA1 that could influence the activity of peroxisome proliferator-activated receptor gamma agonists for prevention. This review explores these possible interactions between peroxisome proliferator-activated receptor gamma, peroxisome proliferator-activated receptor gamma agonists and BRCA1 and discusses feasible experimental directions to provide more definitive information on the potential connections.

Indexed as

AnimalsBRCA1 ProteinBreast NeoplasmsFemaleHumansPPAR gammaBRCA1 ProteinBRCA1 protein, humanPPAR gammaBRCA1breast cancer preventionperoxisome proliferator-activated receptor gammaPPARG agonist

Identifiers

PMID30444720
PMCPMC6494719
OpenAlexW2901656332

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.