ReviewFrontiers of medicine2018
Calorie restriction and its impact on gut microbial composition and global metabolism.
Review in Frontiers of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Untargeted metabolomics reveals effects of calorie restriction on skeletal muscle in older female and male rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Microbiome contribution tobioRxiv : the preprint server for biology · 2026Article
- Content of Fatty Acid and Eicosanoids in Muscle and Intestinal Tissue of C57BL/6 Mice Subjected to Long-Term Caloric Restriction.Nutrients · 2026Article
- Combined effects of calorie restriction and chronic stress on systemic inflammation and gut microbiota in rats exposed toBrain, behavior, & immunity - health · 2025Article
- Surviving on Limited Resources: Effects of Caloric Restriction on Growth, Gene Expression and Gut Microbiota in a Species With Male Pregnancy (Hippocampus erectus).Molecular ecology · 2025Article
- Effects of Long-Term Fasting on Gut Microbiota, Serum Metabolome, and Their Association in Male Adults.Nutrients · 2024Article
- Gut microbiota and healthy longevity.Science China. Life sciences · 2024Review
- Effects of calorie-restricted diet on health state and intestinal flora in Hashimoto's thyroiditis patients: Study protocol for a randomized controlled trial.Asia Pacific journal of clinical nutrition · 2024Article
- Article
- Characterization and shelf life of synbiotic drink powder from porang (Journal of food science and technology · 2024Article
- The Killer's Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer.International journal of molecular sciences · 2024Review
- Eating away cancer: the potential of diet and the microbiome for shaping immunotherapy outcome.Frontiers in immunology · 2024Review
- Caloric Restriction: A Novel Conditioning Strategy to Improve the Survival of Ischemically Challenged Musculocutaneous Random Pattern Flaps.Nutrients · 2023Article
- An Insight into the Exploration of Antibiotic Resistance Genes in Calorie Restricted Diet Fed Mice.Nutrients · 2023Article
- Amino Acid-Derived Bacterial Metabolites in the Colorectal Luminal Fluid: Effects on Microbial Communication, Metabolism, Physiology, and Growth.Microorganisms · 2023Review
- Metabolomics analysis of dietary restriction results in a longer lifespan due to alters of amino acid levels in larval hemolymph of Bombyx mori.Scientific reports · 2023Article
- Temporal Dynamics of the Intestinal Microbiome Following Short-Term Dietary Restriction.Nutrients · 2022Article
- The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?International journal of molecular sciences · 2022Review
- Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice.Nature communications · 2022Article
- Effects of dietary restriction on gut microbiota and CNS autoimmunity.Clinical immunology (Orlando, Fla.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.
Indexed as
Identifiers
30446879What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.