Evidence map›Paper›PMID 30455387›Full record

ArticleBMJ open2018

Which treatment is most effective for patients with patellofemoral pain? A protocol for a living systematic review including network meta-analysis.

Marinus Winters, Sinead Holden, Bill Vicenzino, Nicky J Welton, Deborah M Caldwell, Carolina Bryne Lura, Adam Weir, Michael Skovdal Rathleff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marinus WintersResearch Unit for General Practice in Aalborg, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Sinead HoldenResearch Unit for General Practice in Aalborg, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Bill VicenzinoSchool of Health and Rehabilitation Sciences: Physiotherapy, The University of Queensland, Queensland, Queensland, Australia.
Nicky J WeltonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Deborah M CaldwellPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Carolina Bryne LuraResearch Unit for General Practice in Aalborg, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Adam WeirDepartment of Orthopaedics, Erasmus MC University Medical Center for Groin Injuries, Rotterdam, The Netherlands.
Michael Skovdal RathleffResearch Unit for General Practice in Aalborg, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Funding

Medical Research Council MR/K025643/1Medical Research Council MR/M005615/1
6 · The paper itself

Abstract

introductionPatellofemoral pain (PFP) affects 1 in every 14 adults. Many treatments for PFP have been evaluated, but the comparative effectiveness of all available treatments has never been examined. Network meta-analysis is the only design to study the comparative effectiveness of all available treatments in one synthesis. This protocol describes the methods for a systematic review including network meta-analysis to assess which treatment is most likely to be effective for patients with PFP. METHODS AND ANALYSIS: The primary outcome measures of this network meta-analysis are the global rating of change scale at 6-12 weeks, 13-52 weeks and >52 weeks. The secondary outcome measures are patient-rated pain scales at 6-12 weeks, 13-52 weeks and >52 weeks. Completed published and unpublished randomised controlled trials with full-text reports are eligible for inclusion. We will search Embase, PubMed (including MEDLINE), CENTRAL, Scopus, Web of Science, and CINAHL, SPORTDiscus, OpenGrey, WorldCat, conference Proceedings and multiple trial registers for relevant reports. Two researchers will appraise the study eligibility and perform data extraction. Risk of bias will be assessed with the Cochrane Risk of Bias Tool V.2.0.Bayesian network meta-analyses will be constructed for global rating of change scale and patient-rated pain. Consistency between direct and indirect comparisons will be assessed. Between study variability will be explored, and a threshold analysis for the credibility of the network meta-analyses' conclusions will be performed. ETHICS AND DISSEMINATION: Ethical approval is not required, as this study will be based on published data. The study commenced at 1 February 2018, and its expected completion date is 15 January 2019. Full publication of the work will be sought in an international peer-reviewed journal, as well as translational articles to disseminate the work to clinical practitioners. PROSPERO REGISTRATION NUMBER: CRD42018079502.

Indexed as

Foot OrthosesPatellofemoral Pain SyndromePhysical Therapy ModalitiesGaitHumansMusculoskeletal ManipulationsNetwork Meta-Analysis as TopicPatient Education as TopicSystematic Reviews as Topickneemusculoskeletal disorderssports medicine

Identifiers

PMID30455387
PMCPMC6252644

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.