Evidence map›Paper›PMID 30460869›Full record

ReviewExpert review of medical devices2018

Optical coherence tomography angiography (OCTA) flow speed mapping technology for retinal diseases.

Malvika Arya, Ramy Rashad, Osama Sorour, Eric M Moult, James G Fujimoto, Nadia K Waheed

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of medical devices, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025
    Article
  7. Article
  8. Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Observational
  9. Article
  10. Article
  11. Article
  12. The Impact of Carotid Endarterectomy on Choriocapillaris Perfusion.Investigative ophthalmology & visual science · 2023
    Observational
  13. Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023
    Review
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Malvika Aryaa Department of Ophthalmology , New England Eye Center, Tufts Medical Center , Boston , MA , USA.
Ramy Rashada Department of Ophthalmology , New England Eye Center, Tufts Medical Center , Boston , MA , USA.
Osama Soroura Department of Ophthalmology , New England Eye Center, Tufts Medical Center , Boston , MA , USA.
Eric M Moultc Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA.
James G Fujimotoc Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics , Massachusetts Institute of Technology , Cambridge , MA , USA.
Nadia K Waheeda Department of Ophthalmology , New England Eye Center, Tufts Medical Center , Boston , MA , USA.
Tufts Medical Center · USMassachusetts Institute of Technology · USTanta University · EG

Funding

Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
NEI NIH HHS R01 EY011289
6 · The paper itself

Abstract

introductionOptical coherence tomography angiography (OCTA) is a noninvasive imaging modality for depth-resolved visualization of retinal vasculature. Angiographic data couples with structural data to generate a cube scan, from which en-face images of vasculature can be obtained at various axial positions. OCTA has expanded understanding of retinal vascular disorders and has primarily been used for qualitative analysis. AREAS COVERED: Recent studies have explored the quantitative properties of OCTA, which would allow for objective assessment and follow-up of retinal pathologies. Various quantitative metrics have been developed, such as foveal avascular zone area and vessel density. However, quantitative assessment of the characteristics of retinal blood flow remains limited, as OCTA provides an image depicting either the presence or absence of flow at a particular region without information of relative velocities. The development of variable interscan time analysis (VISTA) overcomes this limitation. The VISTA algorithm generates a color-coded map of relative blood flow speeds. VISTA has already demonstrated utility in furthering our understanding of various retinal pathologies, such as geographic atrophy, choroidal neovascularization, aneurysmal type 1 neovascularization, and diabetic retinopathy. EXPERT COMMENTARY: VISTA, an OCTA flow speed mapping technique, may have a role in developing the utility of OCTA as a screening tool.

Indexed as

AlgorithmsAngiographyHumansRetinal DiseasesRetinal VesselsTomography, Optical Coherenceage-related macular degenerationdiabetic retinopathyflow speed mappingOCTOCTAOptical coherence tomography angiographyquantitative OCTAvariable interscan time analysisVISTA

Identifiers

PMID30460869
PMCPMC6529293
OpenAlexW2900655025

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.