Evidence map›Paper›PMID 30473389›Full record

ReviewEuropean journal of cell biology2019

Cell polarization: From epithelial cells to odontoblasts.

Bei Chang, Kathy K H Svoboda, Xiaohua Liu

Abstract readReview
In one paragraph

Review in European journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. The Role of Autophagy in the Mineralization Process of Bone and Dentin.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Challenges of Studying Amelogenesis in Gene-Targeted Mouse Models.International journal of molecular sciences · 2025
    Review
  9. [Effects of cell area on single odontoblast polarization and differentiation via microarray technology].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. eIF3a Regulates Colorectal Cancer MetastasisFrontiers in cell and developmental biology · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bei ChangDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Kathy K H SvobodaDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Xiaohua LiuDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA. Electronic address: xliu@tamhsc.edu.

Funding

Regeneration of Tubular Vascularized Pulpodentin ComplexR01DE024979 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LIU, XIAOHUA · 2016 to 2020
$1.8M
NIDCR NIH HHS R01 DE024979
6 · The paper itself

Abstract

Cell polarity identifies the asymmetry of a cell. Various types of cells, including odontoblasts and epithelial cells, polarize to fulfil their destined functions. Odontoblast polarization is a prerequisite and fundamental step for tooth development and tubular dentin formation. Current knowledge of odontoblast polarization, however, is very limited, which greatly impedes the development of novel approaches for regenerative endodontics. Compared to odontoblasts, epithelial cell polarization has been extensively studied over the last several decades. The knowledge obtained from epithelia polarization has been found applicable to other cell types, which is particularly useful considering the remarkable similarities of the morphological and compositional features between polarized odontoblasts and epithelia. In this review, we first discuss the characteristics, the key regulatory factors, and the process of epithelial polarity. Next, we compare the known facts of odontoblast polarization with epithelial cells. Lastly, we clarify knowledge gaps in odontoblast polarization and propose the directions for future research to fill the gaps, leading to the advancement of regenerative endodontics.

Indexed as

Cell PolarityAnimalsEpithelial CellsModels, BiologicalOdontoblastsrho GTP-Binding Proteinsrho GTP-Binding ProteinsCell polarityEpithelial cellOdontoblastPolarization

Identifiers

PMID30473389
PMCPMC6338482

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.