Evidence map›Paper›PMID 30482767›Full record

GuidelineBlood advances2018

American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.

Shannon M Bates, Anita Rajasekhar, Saskia Middeldorp, Claire McLintock, Marc A Rodger, Andra H James, Sara R Vazquez, Ian A Greer, John J Riva, Meha Bhatt and 4 more

3 registry-linked trialsAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 216 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05058924 nacompletednot on this mapstarted 2021, after this paper: background citation

Low Molecular Weight hEparin vs. Aspirin Post-partum

TypeinterventionalSponsorMount Sinai Hospital, CanadaRan2021 to 2024Enrolled30ConditionsVenous ThromboembolismArmsProphylactic low molecular weight heparin, Low molecular weight heparin and low-dose aspirin
NCT05318547 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Assessing Women's Preferences for Postpartum Thromboprophylaxis: the PREFER-PostPartum

TypeinterventionalSponsorFondation Hôpital Saint-JosephRan2022 to 2024Enrolled52ConditionsPregnancyArmsstandard-gamble technique, time trade-off technique
NCT07168005 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Does an Informative Video Reduce Anxiety and Pain Before LMWH Treatment Postpartum? - A Randomized Controlled Trial

TypeinterventionalSponsorWolfson Medical CenterRan2025 to 2027Enrolled160ConditionsVenous Thromboembolism (VTE), Postpartum Care, AnxietyArmsInformative Video on LMWH, Standard Verbal Explanation
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shannon M BatesDivision of Hematology and Thromboembolism, Department of Medicine, and.
Anita RajasekharDivision of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL.
Saskia MiddeldorpDepartment of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Claire McLintockNational Women's Health, Auckland City Hospital, Auckland, New Zealand.ORCID 0000-0002-4771-8760
Marc A RodgerFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Andra H JamesDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, NC.
Sara R VazquezDepartment of Pharmacy Services, University of Utah Health Thrombosis Service, Salt Lake City, UT.
Ian A GreerQueens University, Belfast, United Kingdom.
John J RivaDepartment of Family Medicine and.
Meha BhattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Nicole SchwabDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Danielle BarrettWake Forest, NC.
Andrea LaHayeAlexandria, VA; and.
Bram RochwergDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-8293-7061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVenous thromboembolism (VTE) complicates ∼1.2 of every 1000 deliveries. Despite these low absolute risks, pregnancy-associated VTE is a leading cause of maternal morbidity and mortality.

objectiveThese evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians and others in decisions about the prevention and management of pregnancy-associated VTE.

methodsASH formed a multidisciplinary guideline panel balanced to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline development process, including updating or performing systematic evidence reviews. The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess evidence and make recommendations.

resultsThe panel agreed on 31 recommendations related to the treatment of VTE and superficial vein thrombosis, diagnosis of VTE, and thrombosis prophylaxis.

conclusionsThere was a strong recommendation for low-molecular-weight heparin (LWMH) over unfractionated heparin for acute VTE. Most recommendations were conditional, including those for either twice-per-day or once-per-day LMWH dosing for the treatment of acute VTE and initial outpatient therapy over hospital admission with low-risk acute VTE, as well as against routine anti-factor Xa (FXa) monitoring to guide dosing with LMWH for VTE treatment. There was a strong recommendation (low certainty in evidence) for antepartum anticoagulant prophylaxis with a history of unprovoked or hormonally associated VTE and a conditional recommendation against antepartum anticoagulant prophylaxis with prior VTE associated with a resolved nonhormonal provoking risk factor.

Indexed as

Administration, OralAnticoagulantsBreast FeedingEvidence-Based MedicineFemaleFibrinolytic AgentsHeparin, Low-Molecular-WeightHumansInfantInfant, NewbornPregnancyVenous ThromboembolismAnticoagulantsFibrinolytic AgentsHeparin, Low-Molecular-Weight

Identifiers

PMID30482767
PMCPMC6258928

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.