ArticlemBio2018
Origins and Evolution of the Global RNA Virome.
Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 319 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
319 citing papers in PubMed, 520 citations in OpenAlex.
- The origins and evolution of the RNA virome in land flora.Molecular plant · 2026Article
- Diversity of Antarctic sea ice and under-ice seawater RNA viruses.Applied and environmental microbiology · 2026Article
- Why did some viruses evolve to be giants while others did not?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A newly established reverse genetic system for a circular RNA virus reveals new requirements for infection and its biocontrol potential.Science advances · 2026Article
- Identification of Partitivirus-like RdRPs in theViruses · 2026Article
- Highly Divergent Partiti-like and Narna-like Viral RNA Sequences Detected inMicroorganisms · 2026Article
- A generative model for bipartite gene-sharing networks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Concepts of RNA virus evolution for the design of better antiviral countermeasures.Nature reviews. Microbiology · 2026Review
- Diversity and distinctive characteristics of the global RNA virome in urban and peri-urban environments.Nature communications · 2026Article
- Predicting the evolutionary and functional landscapes of viruses with a unified nucleotide-protein language model: LucaVirus.National science review · 2026Article
- Diversity of RNA Viruses in Declining Mediterranean Forests.Microorganisms · 2026Article
- Honghe Bunya-like virus: a novel virus identified in mosquitoes from Yunnan, China.BMC genomics · 2026Article
- Exploring the structural lexicon of the Proteome via Metric Geometry.PLoS computational biology · 2026Article
- Near-complete genome sequences of marna- and nora-like picornaviruses from small pond water in Japan.Microbiology resource announcements · 2026Article
- SARS-CoV-2 nucleocapsid protein variants have differential RNA chaperone activity.The FEBS journal · 2026Article
- ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families.Protein science : a publication of the Protein Society · 2026Article
- The dual-origin hypothesis of viruses under environmental stress and energy crisis.Theory in biosciences = Theorie in den Biowissenschaften · 2026Article
- Identification of hot spring Obelisk-like RNA replicons and expanded diversity of the Obelisk superfamily.Nature communications · 2026Article
- Screening metatranscriptomes for ultrastable RNA secondary structures reveals hidden bacteriophages and novel capsid nanomaterials.bioRxiv : the preprint server for biology · 2026Article
- Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
259 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
Abstract
Viruses with RNA genomes dominate the eukaryotic virome, reaching enormous diversity in animals and plants. The recent advances of metaviromics prompted us to perform a detailed phylogenomic reconstruction of the evolution of the dramatically expanded global RNA virome. The only universal gene among RNA viruses is the gene encoding the RNA-dependent RNA polymerase (RdRp). We developed an iterative computational procedure that alternates the RdRp phylogenetic tree construction with refinement of the underlying multiple-sequence alignments. The resulting tree encompasses 4,617 RNA virus RdRps and consists of 5 major branches; 2 of the branches include positive-sense RNA viruses, 1 is a mix of positive-sense (+) RNA and double-stranded RNA (dsRNA) viruses, and 2 consist of dsRNA and negative-sense (-) RNA viruses, respectively. This tree topology implies that dsRNA viruses evolved from +RNA viruses on at least two independent occasions, whereas -RNA viruses evolved from dsRNA viruses. Reconstruction of RNA virus evolution using the RdRp tree as the scaffold suggests that the last common ancestors of the major branches of +RNA viruses encoded only the RdRp and a single jelly-roll capsid protein. Subsequent evolution involved independent capture of additional genes, in particular, those encoding distinct RNA helicases, enabling replication of larger RNA genomes and facilitating virus genome expression and virus-host interactions. Phylogenomic analysis reveals extensive gene module exchange among diverse viruses and horizontal virus transfer between distantly related hosts. Although the network of evolutionary relationships within the RNA virome is bound to further expand, the present results call for a thorough reevaluation of the RNA virus taxonomy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.