Evidence map›Paper›PMID 30488036›Full record

ArticleFrontiers in molecular biosciences2018

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism

Michael Witting, Janna Hastings, Nicolas Rodriguez, Chintan J Joshi, Jake P N Hattwell, Paul R Ebert, Michel van Weeghel, Arwen W Gao, Michael J O Wakelam, Riekelt H Houtkooper and 8 more

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Computational and structural biotechnology journal · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Quo VadisMetabolites · 2021
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. microPublication biology · 2020
    Article
  16. Review
  17. Article
  18. Frontiers in molecular biosciences · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Michael WittingResearch Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.
Janna HastingsEpigenetics Department, Babraham Institute, Cambridge, United Kingdom.
Nicolas RodriguezEpigenetics Department, Babraham Institute, Cambridge, United Kingdom.
Chintan J JoshiDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, United States.
Jake P N HattwellCentre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Paul R EbertSchool of Biological Sciences, The University of Queensland, Brisbane, QLD, Australia.
Michel van WeeghelLaboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands.
Arwen W GaoLaboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands.
Michael J O WakelamSignaling Department, Babraham Institute, Cambridge, United Kingdom.
Riekelt H HoutkooperLaboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands.
Abraham MainsEpigenetics Department, Babraham Institute, Cambridge, United Kingdom.
Nicolas Le NovèreEpigenetics Department, Babraham Institute, Cambridge, United Kingdom.
Sean SadykoffDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, United States.
Frank SchroederBTI/Cornell University, Ithaca, NY, United States.
Nathan E LewisDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, United States.
Horst-Joachim SchirraCentre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Christoph KaletaResearch Group Medical Systems Biology, Institute of Experimental Medicine, Christian-Albrechts-University Kiel, Kiel, Germany.
Olivia CasanuevaEpigenetics Department, Babraham Institute, Cambridge, United Kingdom.

Funding

Continued Support of Essential SBML Software and Community ResourcesR01GM070923 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HUCKA, MICHAEL · 2004 to 2018
$8.0M
Unraveling the mammalian secretory pathway through systems biology and algorithm developmentR35GM119850 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEWIS, NATHAN ENOCH · 2016 to 2025
$4.3M
Biotechnology and Biological Sciences Research Council BBS/E/B/000C0413European Research Council 638290Medical Research Council MR/M004821/1NIGMS NIH HHS R01 GM070923NIGMS NIH HHS R35 GM119850
6 · The paper itself

Abstract

Metabolism is one of the attributes of life and supplies energy and building blocks to organisms. Therefore, understanding metabolism is crucial for the understanding of complex biological phenomena. Despite having been in the focus of research for centuries, our picture of metabolism is still incomplete. Metabolomics, the systematic analysis of all small molecules in a biological system, aims to close this gap. In order to facilitate such investigations a blueprint of the metabolic network is required. Recently, several metabolic network reconstructions for the model organism

Indexed as

Caenorhabditis elegansmetabolic pathwaysmetabolic reconstructionmetabolismmetabolomics

Identifiers

PMID30488036
PMCPMC6246695

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.