Evidence map›Paper›PMID 30508134›Full record

ArticleSchizophrenia bulletin2019

A Dissociation in Effects of Risperidone Monotherapy on Functional and Anatomical Connectivity Within the Default Mode Network.

Xiaofen Zong, Maolin Hu, Spiro P Pantazatos, J John Mann, Gaohua Wang, Yanhui Liao, Zhong-Chun Liu, Wei Liao, Tao Yao, Zongchang Li and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 2 countries.

Xiaofen ZongDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Maolin HuDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Spiro P PantazatosDivision of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, New York, NY.
J John MannDivision of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, New York, NY.
Gaohua WangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Yanhui LiaoDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhong-Chun LiuDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Wei LiaoKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Tao YaoDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Zongchang LiDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ying HeDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Luxian LvDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Deen SangDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Jinsong TangDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huafu ChenKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Junjie ZhengKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Xiaogang ChenDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Second Xiangya Hospital of Central South University · CNUniversity of Electronic Science and Technology of China · CNCentral South University · CNNew York Psychoanalytic Society and Institute · USWuhan University · CNColumbia University · USHenan Psychiatric Hospital · CNHunan Institute of Mental Health · CNRenmin Hospital of Wuhan University · CNXinxiang Medical University · CN

Funding

Integrative neuroinformatics to relate genomics to neurocircuitry and psychopathologyK01MH108721 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI PANTAZATOS, SPIRO PETER · 2016 to 2019
$739k
NIMH NIH HHS K01 MH108721
6 · The paper itself

Abstract

Respective changes in functional and anatomical connectivities of default mode network (DMN) after antipsychotic treatment have been reported. However, alterations in structure-function coupling after treatment remain unknown. We performed diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging in 42 drug-naive first-episode schizophrenia patients (FESP) both at baseline and after 8-weeks risperidone monotherapy, and in 38 healthy volunteers. Independent component analysis was used to assess voxel-wise DMN synchrony. A 3-step procedure was used to trace fiber paths between DMN components. Structure-function couplings were assessed by Pearson's correlations between mean fractional anisotropy and temporal correlation coefficients in major tracts of DMN. Pretreatment, FESP showed impaired functional connectivity in posterior cingulate cortex/precuneus (PCC/PCUN) and medial prefrontal cortex (mPFC), but no abnormalities in fibers connecting DMN components. After treatment, there were significant increases in functional connectivities of PCC/PCUN. Increases in functional connectivity between PCC/PCUN and mPFC correlated with improvement in positive symptoms. The structure-function coupling in tracts connecting PCC/PCUN and bilateral medial temporal lobes decreased after treatment. No alterations in DMN fiber integrity were detected. This combination of functional and anatomical findings in FESP contributes novel evidence related to neurobehavioral treatment effects. Increased functional connectivities between PCC/PCUN and mPFC may be treatment response biomarkers for positive symptoms. Increases in functional connectivities, no alterations in fiber integrity, combined with decreases in structural-functional coupling, suggest that DMN connectivities may be dissociated by modality after 8-week treatment. Major limitations of this study, however, include lack of repeat scans in healthy volunteers and control group of patients taking placebo or comparator antipsychotics.

Indexed as

AdultAntipsychotic AgentsBrainCase-Control StudiesDiffusion Tensor ImagingFemaleFunctional NeuroimagingGyrus CinguliHumansMaleNeural PathwaysParietal LobePrefrontal CortexRisperidoneSchizophreniaYoung AdultAntipsychotic AgentsRisperidonedefault mode networkdiffusion tensor imaging/risperidonefunctional magnetic resonance imagingschizophrenia

Identifiers

PMID30508134
PMCPMC6811838
OpenAlexW2964105679

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.