ReviewNutrients2018
The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function.
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 74 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Triticum Aestivum Over Vascular Function in Mexican Obese Patients
Longer-term Effects of Wild Blueberry Consumption on Brain Function in Older Men and Women
Who cites it
74 citing papers in PubMed, 4 syntheses or guidelines pooled it, 192 citations in OpenAlex.
- Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- Efficacy of flavonoids-containing supplements on insulin resistance and associated metabolic risk factors in overweight and obese subjects: a systematic review and meta-analysis of 25 randomized controlled trials.Frontiers in endocrinology · 2022Pooled it
- Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.Journal of the International Society of Sports Nutrition · 2021Pooled it
- Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.Nutrients · 2020Pooled it
- Long-term effects of almond consumption on cognitive performance and brain vascular function: a randomized crossover trial in overweight/obese adults with prediabetes.European journal of clinical nutrition · 2026Trial
- Effects of the MIND diet on cardiometabolic health and novel anthropometric measures in women with type 2 diabetes and insomnia: a randomized controlled trial.Nutrition journal · 2025Trial
- Trial
- Hesperetin-7-Nutrients · 2023Trial
- Trial
- The Effect of Long-TermNutrients · 2020Trial
- Trial
- Altitude-Dependent Differences in Non-Volatile Metabolites of Tea Leaves Revealed by Widely Targeted Metabolomics.Biology · 2026Article
- Linking phytochemistry to bioactivity:Frontiers in chemistry · 2026Article
- Dietary Flavonoids as Cross-System Modulators of Hypertension and Intestinal Permeability.Molecules (Basel, Switzerland) · 2025Review
- Exploring Individual Factors Affecting Endothelial Function Response Variability in Aging: Implications for Precision Nutrition.Nutrients · 2025Review
- Seasonal Dynamic Changes in the Nutrient Elements and Antioxidant Activity ofPlants (Basel, Switzerland) · 2025Article
- Tea Catechins: Potential Plant-Derived Feed Additives for Improving Chicken Intestinal Health and Productivity.Animals : an open access journal from MDPI · 2025Article
- A Comprehensive Polyphenolic Characterization of Five Montmorency Tart Cherry (Foods (Basel, Switzerland) · 2025Article
- Red Currant (Plants (Basel, Switzerland) · 2025Article
- The relationship between dietary flavonoid intake and hypertension: a cross-sectional study from NHANES.Frontiers in cardiovascular medicine · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research has suggested a number of beneficial effects arising from the consumption of dietary flavonoids, found in foods such as cocoa, apples, tea, citrus fruits and berries on cardiovascular risk factors such as high blood pressure and endothelial dysfunction. These effects are thought to have a significant impact upon both vascular and cerebrovascular health, ultimately with the potential to prevent cardiovascular and potentially neurodegenerative disease with a vascular component, for example vascular dementia. This review explores the current evidence for the effects of flavonoid supplementation on human endothelial function and both peripheral and cerebral blood flow (CBF). Evidence presented includes their potential to reduce blood pressure in hypertensive individuals, as well as increasing peripheral blood perfusion and promoting CBF in both healthy and at-risk populations. However, there is great variation in the literature due to the heterogeneous nature of the randomised controlled trials conducted. As such, there is a clear need for further research and understanding within this area in order to maximise potential health benefits.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.