Evidence map›Paper›PMID 30515696›Full record

ArticleMolecular biology reports2019

Identification of porcine CTLA4 gene polymorphism and their association with piglet diarrhea and performance traits.

Xiaowen Gao, Dongchun Guo, Mingxing Kou, Guiling Xing, Andong Zha, Xiuqin Yang, Xibiao Wang, Shengwei Di, Jiancheng Cai, Buyue Niu

Abstract read
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In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaowen GaoCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Dongchun GuoState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Harbin, 150001, China.
Mingxing KouCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Guiling XingCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Andong ZhaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Xiuqin YangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Xibiao WangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Shengwei DiCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Jiancheng CaiLanxi breeding Farm, Lanxi, 151500, China.
Buyue NiuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China. niubuyue@neau.edu.cn.ORCID http://orcid.org/0000-0003-1491-3903
Northeast Agricultural University · CNChinese Academy of Agricultural Sciences · CN

Funding

National Natural Science Foundation of China 31301935Science and technology foundation of Education Department, Heilongjiang Province 12541005
6 · The paper itself

Abstract

The objective of this study was to evaluate the association between the cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) gene and piglet diarrhea. In this study, the mRNA expression of the CTLA4 gene increased significantly in IPEC-J2 cells after Escherichia coli K88 infection. Single nucleotide polymorphisms (SNPs) located in the 5' flanking region (SNPs g.107281989C>T) and 3'-untranslated region (3'-UTR; SNPs g.107288753C>A) were identified, and they were in linkage disequilibrium in both Min pigs and the Landrace population. Association analysis showed that Landrace piglets with a TT or AA genotype had a lower diarrhea index, and AA animals had higher average daily gain when compared to CC pigs, respectively (p < 0.05). However, the relationship between SNPs and diarrhea and performance traits in the Min population was not significant. Haplotype analysis indicated that the TC haplotype had the lowest diarrhea index. The 5' flanking deletion assay suggested that SNP g.107281989C>T was a molecular marker instead of the functional marker. This research demonstrated that genetic variances in the CTLA4 gene had significant effects on Landrace piglet diarrhea resistance.

Indexed as

Genetic Association StudiesQuantitative Trait, Heritable5' Flanking RegionAnimalsAnimals, NewbornBreedingCell LineCTLA-4 AntigenDiarrheaGenetics, PopulationHaplotypesLinkage DisequilibriumPolymorphism, Single NucleotideSequence DeletionSwineCTLA-4 AntigenCTLA4 geneDiarrheaHaplotypePigPolymorphism

Identifiers

PMID30515696
OpenAlexW2902293347

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.