Evidence map›Paper›PMID 30519983›Full record

ArticleNeurochemical research2019

Effect of Silk Fibroin on Neuroregeneration After Traumatic Brain Injury.

M M Moisenovich, E Y Plotnikov, A M Moysenovich, D N Silachev, T I Danilina, E S Savchenko, M M Bobrova, L A Safonova, V V Tatarskiy, M S Kotliarova and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  7. Article
  8. Review
  9. Heliyon · 2022
    Review
  10. Review
  11. Bio-Scaffolds as Cell or Exosome Carriers for Nerve Injury Repair.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M M MoisenovichBiological Faculty, Lomonosov Moscow State University, Moscow, Russia.
E Y PlotnikovA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
A M MoysenovichBiological Faculty, Lomonosov Moscow State University, Moscow, Russia.
D N SilachevA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
T I DanilinaFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
E S SavchenkoFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
M M BobrovaBiological Faculty, Lomonosov Moscow State University, Moscow, Russia.
L A SafonovaBiological Faculty, Lomonosov Moscow State University, Moscow, Russia.
V V TatarskiyN.N. Blokhin Russian Cancer Research Center, Moscow, Russia.
M S KotliarovaBiological Faculty, Lomonosov Moscow State University, Moscow, Russia.
I I AgapovBiological Faculty, Lomonosov Moscow State University, Moscow, Russia.
D B ZorovA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. zorov@belozersky.msu.ru.ORCID http://orcid.org/0000-0003-0863-8490

Funding

Russian Foundation for Basic Research 17-00-00359Russian Science Foundation 14-24-00107
6 · The paper itself

Abstract

Traumatic brain injury is one of the leading causes of disability among the working-age population worldwide. Despite attempts to develop neuroprotective therapeutic approaches, including pharmacological or cellular technologies, significant advances in brain regeneration have not yet been achieved. Development of silk fibroin-based biomaterials represents a new frontier in neuroregenerative therapies after brain injury. In this study, we estimated the short and long-term effects of silk fibroin scaffold transplantation on traumatic brain injury and biocompatibility of this biomaterial within rat neuro-vascular cells. Silk fibroin microparticles were injected into a brain damage area 1 day after the injury. Silk fibroin affords neuroprotection as judged by diminished brain damage and recovery of long-term neurological functions. We did not detect considerable toxicity to neuro-vascular cells cultured on fibroin/fibroin-gelatin microparticles in vitro. Cultivation of primary cell cultures of neurons and astrocytes on silk fibroin matrices demonstrated their higher viability under oxygen-glucose deprivation compared to 2D conditions on plastic plates. Thus, we conclude that scaffolds based on silk fibroin can become the basis for the creation of constructs aimed to treat brain regeneration after injury.

Indexed as

AnimalsBiocompatible MaterialsBrain Injuries, TraumaticCell ProliferationCells, CulturedDisease Models, AnimalFibroinsNerve RegenerationRatsTissue ScaffoldsBiocompatible MaterialsFibroinsAstrocytesFibroinIschemiaNeuronsNeuroprotectionScaffold

Identifiers

PMID30519983

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.