Evidence map›Paper›PMID 30520965›Full record

ArticleBioinformatics (Oxford, England)2019

Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics.

Gregory McInnes, Yosuke Tanigawa, Chris DeBoever, Adam Lavertu, Julia Eve Olivieri, Matthew Aguirre, Manuel A Rivas

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. A haplotype-resolved view of human gene regulation.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Deciphering epistatic genetic regulation of cardiac hypertrophy.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Prospective study design and data analysis in UK Biobank.Science translational medicine · 2024
    Review
  14. Machine Learning Strategies for Improved Phenotype Prediction in Underrepresented Populations.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gregory McInnesBiomedical Informatics Training Program, Stanford University, CA, USA.
Yosuke TanigawaBiomedical Informatics Training Program, Stanford University, CA, USA.
Chris DeBoeverDepartment of Biomedical Data Science, Stanford University, CA, USA.
Adam LavertuBiomedical Informatics Training Program, Stanford University, CA, USA.
Julia Eve OlivieriInstitute for Computational and Mathematical Engineering, Stanford University, CA, USA.
Matthew AguirreDepartment of Biomedical Data Science, Stanford University, CA, USA.
Manuel A RivasDepartment of Biomedical Data Science, Stanford University, CA, USA.

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Optimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2M
SOFTWARE FOR LARGE-SCALE INFERENCE OF THE GENETICS OF LIFESTYLE MEASURES, BIOMARKERS, AND COMMON AND RARE DISEASESR01HG010140 · NHGRI · STANFORD UNIVERSITY · PI KUNDAJE, ANSHUL, MONTGOMERY, STEPHEN · 2018 to 2022
$2.0M
Biomedical Data Science Graduate Training at StanfordT32LM012409 · NLM · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2016 to 2020
$1.5M
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHGRI NIH HHS R01 HG010140NHGRI NIH HHS U01 HG009080NLM NIH HHS T15 LM007033NLM NIH HHS T32 LM012409
6 · The paper itself

Abstract

summaryLarge biobanks linking phenotype to genotype have led to an explosion of genetic association studies across a wide range of phenotypes. Sharing the knowledge generated by these resources with the scientific community remains a challenge due to patient privacy and the vast amount of data. Here, we present Global Biobank Engine (GBE), a web-based tool that enables exploration of the relationship between genotype and phenotype in biobank cohorts, such as the UK Biobank. GBE supports browsing for results from genome-wide association studies, phenome-wide association studies, gene-based tests and genetic correlation between phenotypes. We envision GBE as a platform that facilitates the dissemination of summary statistics from biobanks to the scientific and clinical communities. AVAILABILITY AND IMPLEMENTATION: GBE currently hosts data from the UK Biobank and can be found freely available at biobankengine.stanford.edu.

Indexed as

Biological Specimen BanksGenome-Wide Association StudyGenotypeHumansPhenomicsPhenotype

Identifiers

PMID30520965
PMCPMC6612820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.