Evidence map›Paper›PMID 30523620›Full record

ArticleCancer treatment and research

Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis.

Meilan He, Fan Cheng, Suzane Ramos da Silva, Brandon Tan, Océane Sorel, Marion Gruffaz, Tingting Li, Shou-Jiang Gao

Abstract read
In one paragraph

Article in Cancer treatment and research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Animal models of human herpesvirus infection.Animal models and experimental medicine · 2025
    Review
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. NAT10-dependent NNature communications · 2023
    Article
  13. Article
  14. mViruses · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Metabolic Control by DNA Tumor Virus-Encoded Proteins.Pathogens (Basel, Switzerland) · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meilan HeDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Fan ChengDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Suzane Ramos da SilvaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Brandon TanDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Océane SorelDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Marion GruffazDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Tingting LiDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Shou-Jiang GaoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA. shoujiag@usc.edu.

Funding

Cell Model for KSHV Infection and Genetic ManipulationR01CA096512 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Shou-Jiang Gao · 2003 to 2026
$7.4M
Regulation of KSHV replication by N6-methyladenosine (m6A) - Diversity SupplementR01CA124332 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GAO, SHOU-JIANG · 2007 to 2025
$5.0M
Mechanism of KSHV-induced angiogenesisR01CA132637 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GAO, SHOU-JIANG · 2008 to 2020
$3.6M
Targeting KSHV malignancies and persistent infectionR01CA197153 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAO, SHOU-JIANG · 2015 to 2019
$1.9M
KSHV microRNAs in tumor invasion and angiogenesisR01CA213275 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAO, SHOU-JIANG · 2017 to 2021
$959k
NCI NIH HHS R01 CA096512NCI NIH HHS R01 CA124332NCI NIH HHS R01 CA132637NCI NIH HHS R01 CA197153NCI NIH HHS R01 CA213275
6 · The paper itself

Abstract

Discovered in 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) has been associated with four human malignancies including Kaposi's sarcoma, primary effusion lymphoma, a subset of multicentric Castleman's disease, and KSHV inflammatory cytokine syndrome. These malignancies mostly occur in immunocompromised patients including patients with acquired immunodeficiency syndrome and often cause significant mortality because of the lack of effective therapies. Significant progresses have been made to understand the molecular basis of KSHV infection and KSHV-induced oncogenesis in the last two decades. This chapter provides an update on the recent advancements focusing on the molecular events of KSHV primary infection, the mechanisms regulating KSHV life cycle, innate and adaptive immunity, mechanism of KSHV-induced tumorigenesis and inflammation, and metabolic reprogramming in KSHV infection and KSHV-transformed cells.

Indexed as

Acquired Immunodeficiency SyndromeCarcinogenesisCastleman DiseaseCoinfectionCytokinesHerpesviridae InfectionsHerpesvirus 8, HumanHIV InfectionsHumansImmunocompromised HostInflammationLymphoma, Primary EffusionNeoplasmsSarcoma, KaposiSyndromeViremiaCytokines

Identifiers

PMID30523620
PMCPMC7119181

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.