Evidence map›Paper›PMID 30524281›Full record

ReviewFrontiers in pharmacology2018

Anabolic Androgenic Steroids: Searching New Molecular Biomarkers.

Francesco Sessa, Monica Salerno, Giulio Di Mizio, Giuseppe Bertozzi, Giovanni Messina, Benedetta Tomaiuolo, Daniela Pisanelli, Francesca Maglietta, Pietrantonio Ricci, Cristoforo Pomara

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Nandrolone Decanoate: Use, Abuse and Side Effects.Medicina (Kaunas, Lithuania) · 2020
    Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review
  7. Article
  8. Impacts of Anabolic-androgenic steroid supplementation on female health and offspring: Mechanisms, side effects, and medical perspectives.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  9. Article
  10. Article
  11. The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health.International journal of molecular sciences · 2022
    Review
  12. Effects of Mixed of a Ketogenic Diet in Overweight and Obese Women with Polycystic Ovary Syndrome.International journal of environmental research and public health · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Francesco SessaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Monica SalernoDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giulio Di MizioDepartment of Legal, Historical, Economic and Social Sciences, University of Catanzaro, Catanzaro, Italy.
Giuseppe BertozziDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giovanni MessinaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Benedetta TomaiuoloDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Daniela PisanelliDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Francesca MagliettaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Pietrantonio RicciDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Cristoforo PomaraDepartment of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy.
University of Foggia · ITMagna Graecia University · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even if anabolic androgenic steroid (AAS) abuse is clearly associated with a wide spectrum of collateral effects, adolescents and athletes frequently use a large group of synthetic derivatives of testosterone, both for aesthetic uses and for improving performance. Over the last few years, the development of MicroRNA (miRNA) technologies has become an essential part of research projects and their role as potential molecular biomarkers is being investigated by the scientific community. The circulating miRNAs detection as a diagnostic or prognostic tool for the diagnosis and treatment of several diseases is very useful, because with a minimal quantity of sample (peripheral blood), miRNAs are very sensitive. Even more, miRNAs remain stable both at room temperature and during freeze-thaw cycles. These characteristics highlight the important role of miRNAs in the near future as new tools for anti-doping. The article provides a systematic review and meta-analysis on the role of miRNAs as new potential molecular biomarkers of AAS use/abuse. Particularly, this paper analyzed the "miRNA signature" use as biomarkers for health disorders, focusing on the organ damages which are related to ASS use/abuse. Moreover, this review aims to provide a future prospect for less invasive or non-invasive procedures for the detection of circulating miRNA biomarkers as doping assumption signaling.

Indexed as

adverse effectsanabolic androgenic steroids (AASs)dopingmiRNAsnew molecular biomarkers

Identifiers

PMID30524281
PMCPMC6256094
OpenAlexW2901005954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.