Evidence map›Paper›PMID 30524671›Full record

ArticleIranian journal of basic medical sciences2018

Kalirin-7 plays a neuroprotective role in Neuro-2A cells injured by oxygen-glucose deprivation and reperfusion through Rac1 activation.

Jian Xu, Yanxiu Chen, Zeyu Wu, Yihe Dou, Peng Lun, Peng Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jian XuDepartment of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao 266500, China.
Yanxiu ChenDepartment of Neurology, Liaocheng People's Hospital, Liaocheng 252000, China.
Zeyu WuDepartment of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao 266500, China.
Yihe DouDepartment of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao 266500, China.
Peng LunDepartment of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao 266500, China.
Peng SunDepartment of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao 266500, China.
Liaocheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe study explored the neuroprotective role of Kalirin-7 (Kal-7) in Neuro-2A cells after oxygen-glucose deprivation and reperfusion (OGD/R) treatment. MATERIALS AND

methodsThe study used an OGD/R model of mouse Neuro-2A neuroblastoma cells

resultsKal-7 significantly decreased OGD/R induced cell apoptosis (

conclusionThese findings suggest that the protective effects of Kal-7 against OGD/R injury in Neuro-2A cells were dependent in a Rac1 activation signaling.

Indexed as

Anti-apoptosisKalirin-7NeuroprotectionOGD/RRac1

Identifiers

PMID30524671
PMCPMC6281060
OpenAlexW2893689347

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.