Evidence map›Paper›PMID 30530599›Full record

ArticleAntimicrobial agents and chemotherapy2019

Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development.

Peng Xu, Safder S Ganaie, Xiaomei Wang, Zekun Wang, Steve Kleiboeker, Nancy C Horton, Richard F Heier, Marvin J Meyers, John E Tavis, Jianming Qiu

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Peng XuDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Safder S GanaieDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-9014-6577
Xiaomei WangDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Zekun WangDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Steve KleiboekerViraCor Eurofins Laboratories, Lee's Summit, Missouri, USA.
Nancy C HortonDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA.
Richard F HeierCenter for World Health and Medicine, Saint Louis University, St. Louis, Missouri, USA.
Marvin J MeyersCenter for World Health and Medicine, Saint Louis University, St. Louis, Missouri, USA.
John E TavisDepartment of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, USA.
Jianming QiuDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA jqiu@kumc.edu.
University of Kansas Medical Center · USSaint Louis University · USEurofins (United States) · USUniversity of Arizona · US

Funding

Post-Transcriptional Regulation of Parvovirus Capsid Gene ExpressionR01AI070723 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2007 to 2017
$3.3M
A screen for antiviral compounds targeting the Hepatitis B Virus ribonuclease HR01AI104494 · NIAID · SAINT LOUIS UNIVERSITY · PI TAVIS, JOHN E · 2014 to 2016
$1.0M
Defining approaches for improving HID and HPD compounds as HBV RNaseH antagonistsR21AI124672 · NIAID · SAINT LOUIS UNIVERSITY · PI MEYERS, MARVIN J, TAVIS, JOHN E · 2017 to 2018
$417k
Post-Transcriptional Regulation of Parvovirus Capsid Gene ExpressionR56AI070723 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2006 to 2006
$290k
NIAID NIH HHS R01 AI070723NIAID NIH HHS R01 AI104494NIAID NIH HHS R21 AI124672NIAID NIH HHS R56 AI070723
6 · The paper itself

Abstract

Human parvovirus B19 (B19V), a member of the genus

Indexed as

Antiviral AgentsCell LineDNA ReplicationDNA, ViralDrug DevelopmentErythroid Precursor CellsHumansParvoviridae InfectionsParvovirus B19, HumanViral Nonstructural ProteinsVirus ReplicationAntiviral AgentsDNA, ViralNS1 protein, parvovirusViral Nonstructural Proteinsantiviralsin vitro nicking assayparvovirus B19

Identifiers

PMID30530599
PMCPMC6395930
OpenAlexW2904221482

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.