Evidence map›Paper›PMID 30530623›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Diuretic, Natriuretic, and Vasodepressor Activity of a Lipid Fraction Enhanced in Medium of Cultured Mouse Medullary Interstitial Cells by a Selective Fatty Acid Amide Hydrolase Inhibitor.

Zdravka Daneva, Sara K Dempsey, Ashfaq Ahmad, Ningjun Li, Pin-Lan Li, Joseph K Ritter

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Renomedullary Interstitial Cell Endothelin A Receptors Regulate BP and Renal Function.Journal of the American Society of Nephrology : JASN · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zdravka DanevaDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Sara K DempseyDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Ashfaq AhmadDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Ningjun LiDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Pin-Lan LiDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Joseph K RitterDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia jritter@vcu.edu.
Virginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7M
VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOLENE J WINDLE · 2014 to 2026
$13.8M
Renal Medullary HIF Prolyl Hydroxylases and Salt Sensitivity of Blood PressureR01HL089563 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2007 to 2016
$3.4M
Lysosome dysfunction in podocytopathy and associated hypertensionR01DK120491 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN · 2018 to 2022
$2.4M
Renal sphingosine-1-phosphate receptor 1 in salt-sensitive hypertensionR01HL145163 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2019 to 2022
$1.6M
Renomedullary metabolism of anandamide and blood pressure regulationR01DK102539 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN, RITTER, JOSEPH K. · 2016 to 2019
$1.4M
Molecular mechanism of hypertension-induced renal injury: the role of HIF-1alphaR01DK107991 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2017 to 2019
$698k
NCI NIH HHS P30 CA016059NHLBI NIH HHS R01 HL089563NHLBI NIH HHS R01 HL145163NIDA NIH HHS P30 DA033934NIDA NIH HHS T32 DA007027NIDDK NIH HHS R01 DK102539NIDDK NIH HHS R01 DK107991NIDDK NIH HHS R01 DK120491
6 · The paper itself

Abstract

The relationship between the endocannabinoid system in the renal medulla and the long-term regulation of blood pressure is not yet understood. To investigate the possible role of the endocannabinoid system in renomedullary interstitial cells, mouse medullary interstitial cells (MMICs) were obtained, cultured, and characterized for their responses to treatment with a selective inhibitor of fatty acid amide hydrolase, PF-3845 (

Indexed as

AmidohydrolasesAnimalsBlood PressureCells, CulturedDiuresisDiureticsFatty Acid Amide HydrolasesFemaleKidney MedullaMaleMiceMice, Inbred C57BLMice, KnockoutNatriuresisPiperidinesPyridinesAmidohydrolasesDiureticsFatty Acid Amide HydrolasesPF 3845PiperidinesPyridines

Identifiers

PMID30530623
PMCPMC6337005
OpenAlexW2903714609

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.