ArticleScientific reports2018
Sequencing the mosaic genome of Brahman cattle identifies historic and recent introgression including polled.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 71 citations in OpenAlex.
- Implementation of Metafounders in the Genomic Prediction for the Polled Trait in Brahman Cattle Using a Multi-Breed Population.Animal genetics · 2026Article
- Genomic analysis of breed composition and population structure in Montana composite cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- A genome-wide assessment of the population structure of thirteen admixed and pure Australian beef cattle breeds.Journal of animal science · 2026Article
- Selective sweeps for mutations increasing height impede identification of causative mutations for fertility and other correlated traits in cattle.Genetics, selection, evolution : GSE · 2025Article
- Identification and Validation of Genus/Species-Specific Short InDels in Dairy Ruminants.BMC veterinary research · 2025Article
- Strategies for genomic predictions of an indicine multi-breed population using single-step GBLUP.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Genetic architecture of thermotolerance traits in beef cattle: a novel integration of SNP and breed-of-origin effects.Frontiers in genetics · 2025Article
- Concurrently mapping quantitative trait loci associations from multiple subspecies within hybrid populations.Heredity · 2023Article
- Profiling the immune epigenome across global cattle breeds.Genome biology · 2023Article
- Genetic Structure Analysis of 155 Transboundary and Local Populations of Cattle (International journal of molecular sciences · 2023Article
- Correlation scan: identifying genomic regions that affect genetic correlations applied to fertility traits.BMC genomics · 2022Article
- Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations.iScience · 2022Article
- Genetic variation in PLAG1 is associated with early fertility in Australian Brahman cattle.Journal of animal science · 2022Article
- Characterization of runs of homozygosity, heterozygosity-enriched regions, and population structure in cattle populations selected for different breeding goals.BMC genomics · 2022Article
- Assessing accuracy of genotype imputation in the Afrikaner and Brahman cattle breeds of South Africa.Tropical animal health and production · 2022Article
- Mitonuclear incompatibility as a hidden driver behind the genome ancestry of African admixed cattle.BMC biology · 2022Article
- Assessing Bos taurus introgression in the UOA Bos indicus assembly.Genetics, selection, evolution : GSE · 2021Article
- Investigating the impact of reference assembly choice on genomic analyses in a cattle breed.BMC genomics · 2021Article
- Novel functional sequences uncovered through a bovine multiassembly graph.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Imputation accuracy to whole-genome sequence in Nellore cattle.Genetics, selection, evolution : GSE · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brahman cattle have a Bos indicus and Bos taurus mosaic genome, as a result of the process used to create the breed (repeat backcrossing of Bos taurus females to Bos indicus bulls). With the aim of identifying Bos taurus segments in the Brahman genome at sequence level resolution, we sequenced the genomes of 46 influential Brahman bulls. Using 36 million variants identified in the sequences, we searched for regions close to fixation for Bos indicus or Bos taurus segments that were longer than expected by chance (from simulation of the breed formation history of Brahman cattle). Regions close to fixation for Bos indicus content were enriched for protein synthesis genes, while regions of higher Bos taurus content included genes of the G-protein coupled receptor family (including genes implicated in puberty, such as THRS). The region with the most extreme Bos taurus enrichment was on chromosome 14 surrounding PLAG1. The introgressed Bos taurus allele at PLAG1 increases stature and the high frequency of the allele likely reflects strong selection for the trait. Finally, we provide evidence that the polled mutation in Brahmans, a desirable trait under very strong recent selection, is of Celtic origin and is introgressed from Bos taurus.
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