Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration.

Koji Nonaka, Yutaka Ozaki, Kenichi Ito, Masahiro Sakita, Satsuki Une, Junichi Akiyama

Abstract read

In one paragraph

Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

Experimental and therapeutic medicine · 2020
Article

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Koji NonakaDepartment of Physical Therapy, Faculty of Health Sciences, Kyoto Tachibana University, 34 Oyakeyamada-cho, Yamashina-ku, Kyoto, Kyoto, 607-8175, Japan. nonaka-k@tachibana-u.ac.jp.ORCID http://orcid.org/0000-0002-7176-9656

Yutaka OzakiDepartment of Rehabilitation, Kansai Electric Power Hospital, Osaka, Japan.

Kenichi ItoFaculty of Health Sciences, Naragakuen University, Nara, Japan.

Masahiro SakitaDepartment of Physical Therapy, Faculty of Health Sciences, Kyoto Tachibana University, 34 Oyakeyamada-cho, Yamashina-ku, Kyoto, Kyoto, 607-8175, Japan.

Satsuki UneFaculty of Education, Kagawa University, Takamatsu, Kagawa, Japan.

Junichi AkiyamaDepartment of Physical Therapy, School of Health Care and Social Welfare, Kibi International University, Takahashi, Okayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins and exercise reduce cardiovascular disease incidence. We investigated whether endurance exercise in mice induces mitochondrial adaptation in skeletal muscle and muscle injury during administration of atorvastatin, a member of the statin medication class. Male C57BL mice were assigned to one of three groups: control (Con), statin (Statin), or statin and exercise (Statin + Ex). Atorvastatin was administered, and exercise performed on a treadmill for 8 weeks. The levels of mitochondria-associated proteins, PGC-1α, and respiratory chain complex, (COX) I-V, in the quadriceps femoris, and serum creatine kinase, a muscle injury marker, were measured. PGC-1α and COX I-V were upregulated in the Statin + Ex group compared to those in the Statin and Con groups; serum creatine kinase levels were similar. Endurance training in mice induced mitochondrial adaptation in skeletal muscle without causing muscle injury, during atorvastatin administration.

Indexed as

Adaptation, PhysiologicalAnimalsAtorvastatinCreatine KinaseElectron TransportHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiceMice, Inbred C57BLMitochondria, MuscleMuscle, SkeletalPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhysical Conditioning, AnimalQuadriceps MuscleAtorvastatinCreatine KinaseHydroxymethylglutaryl-CoA Reductase InhibitorsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseExerciseMuscle injuryPGC-1αRespiratory chain complexesStatin

Identifiers

PMID30536041

DOI10.1007/s12576-018-0649-x

PMCPMC10717863

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.