ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2018
Madelung's disease - progressive, excessive, and symmetrical deposition of adipose tissue in the subcutaneous layer: case report and literature review.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Multiple symmetric lipomatosis (Madelung disease) presenting as cervical lipomatous mass in a middle-aged male with alcohol use in Nepal: A Case Report.BMC surgery · 2026Article
- Madelung Disease Associated With Bilateral Avascular Necrosis of the Femoral Head: A Case Report of a Rare Disorder.Cureus · 2026Article
- Madelung's disease involving the scrotum: a case report and diagnostic pitfalls with liposarcoma.Frontiers in oncology · 2026Article
- Adipocytes from lipedema adipose tissue show lipoma-associated nuclear atypia.Frontiers in cell and developmental biology · 2026Article
- Effects of Dielectric Properties of Human Body on Communication Link Margins and Specific Absorption Rate of Implanted Antenna System.Sensors (Basel, Switzerland) · 2025Article
- A Case Report of Madelung's Disease in Romania.Diagnostics (Basel, Switzerland) · 2025Article
- Madelung's disease -a case series from a single-center experience.Frontiers in surgery · 2025Article
- A case report on Madelung's disease and comprehensive review of the literature.Orphanet journal of rare diseases · 2024Review
- Madelung's Disease Evolving to Liposarcoma: An Uncommon Encounter.Life (Basel, Switzerland) · 2024Article
- Madelung disease with postoperative priapism and multiple venous thromboses: case report and literature review.Frontiers in cardiovascular medicine · 2024Article
- Multiple symmetric lipomatosis with chronic kidney disease and tophi.Oxford medical case reports · 2023Article
- Article
- Exploration of Influencing Factors for Postoperative Recurrence in Patients with Madelung's Disease on the Basis of Multivariate Stepwise Cox Regression Analysis.Clinical, cosmetic and investigational dermatology · 2023Article
- Madelung's Disease as an Example of a Metabolic Disease Associated with Alcohol Abuse-Diagnostic Importance of Computed Tomography.International journal of environmental research and public health · 2022Article
- A case report of Madelung's disease in China.Radiology case reports · 2022Article
- Proptosis of the eye: a potential form of Madelung's disease.BMJ case reports · 2021Article
- Multidisciplinary diagnostic dilemma in differentiating Madelung's disease - the value of superb microvascular imaging technique: A case report.World journal of clinical cases · 2021Article
- A non-alcohol-related case of Madelung's disease: Challenging patient with progressive jugular vein distension.Radiology case reports · 2021Article
- Madelung disease: A case report.World journal of clinical cases · 2021Article
- Giant bilateral primary scrotal lipoma along with lipomas in multiple sites of the body: a case report and literature review.Translational andrology and urology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Madelung's disease is a rare disorder described for the first time in the year 1846 by Brodie. It is characterized by the occurrence of progressive, excessive, and symmetrical deposits of adipose tissue in the subcutaneous layer. Most often, these changes concern the neck, the nape of the neck, arms, and upper back, giving the patients a specific, pseudoathletic appearance. Madelung's disease is also known as multiple symmetrical lipomatosis, benign symmetrical lipomatosis, and Launois-Bensaude syndrome. The most commonly affected ones are men who drink alcohol in excessive amounts. The fat masses emerging in the course of the disease are painless but can lead to adverse repercussions. Patients may experience dysphagia, dysphonia, difficulty in breathing, and limited mobility of the neck. The reasons for the willingness to take up treatment are also often esthetic reasons. The disease is usually accompanied by numerous metabolic disorders. The etiology of the disease has not been sufficiently explained so far, which creates diagnostic and therapeutic difficulties. Currently used treatment is limited to surgical resection of the resulting lesions or liposuction. Unfortunately, the effectiveness of these activities is limited. Most patients experience recurrence after treatment. This paper discusses the essence of Madelung's disease, numerous aspects of etiology, the manner of diagnosis, and treatment based on current literature data.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.