Evidence map›Paper›PMID 30539265›Full record

SynthesisInternational journal of colorectal disease2019

Probiotics for preventing postoperative infection in colorectal cancer patients: a systematic review and meta-analysis.

Xiaojing Ouyang, Qingfeng Li, Mengjing Shi, Dongsheng Niu, Wenjing Song, Qinggong Nian, Xiangda Li, Zhonghui Ding, Xianyin Ai, Jian Wang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Review
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  13. The Role of Probiotics in Colorectal Cancer: A Review.Journal of gastrointestinal cancer · 2023
    Review
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  15. Review
  16. Article
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  18. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021
    Article
  19. Review
  20. The Role of Probiotics in Colorectal Cancer Management.Evidence-based complementary and alternative medicine : eCAM · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaojing OuyangDepartment of Gastroenterology, The Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
Qingfeng LiCenter for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.
Mengjing ShiCenter for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.
Dongsheng NiuBeijing Prevention and Treatment Hospital of Occupational Disease for Chemical Industry, Beijing, China.
Wenjing SongCenter for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.
Qinggong NianCenter for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.
Xiangda LiCenter for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.
Zhonghui DingCenter for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.
Xianyin AiMedical Company of 32143 Force, Xinyang, Henan Province, China.
Jian WangCenter for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China. wellginger1987@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostoperative infection has seriously affected the prognosis of cancer patients, while probiotics have been increasingly used to prevent postoperative infection in clinical practice. This study aimed to evaluate the preventive effect of probiotics on infection after colorectal cancer (CRC) surgery.

methodsRelated clinical trial reports were collected from Pubmed, Embase, Cochrane Library as well as China National Knowledge Infrastructure (CNKI) databases. These reports were then strictly screened, and information as well as data were extracted. Finally, the enrolled studies were evaluated by systematic review and meta-analysis using STATA v11 and Revman v5.2.

resultsProbiotics administration contributed to the reduction of overall infection rate after colorectal surgery, with a pooled odds ratio (OR) of 0.51 (95% CI: 0.38-0.68, P = 0.00). Meanwhile, the incidence of incision infection (pooled OR = 0.59, 95% CI 0.39-0.88, P = 0.01) and pneumonia (pooled OR = 0.56, 95% CI 0.32-0.98, P = 0.04) as well as the first flatus time (SMDs = - 0.70, 95% CI - 1.13-- 0.27, P = 0.002) were also reduced by probiotics. In addition, urinary tract infection, anastomotic leakage, and duration of postoperative pyrexia were also analyzed, which displayed no statistical differences compared with those of control.

conclusionProbiotics have potential efficacy on preventing postoperative infection and related complications in cancer patients undergoing colorectal surgery.

Indexed as

Colorectal NeoplasmsHumansOdds RatioProbioticsPublication BiasSurgical Wound InfectionColorectal surgeryMeta-analysisPostoperative infectionProbiotics

Identifiers

PMID30539265

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.