Evidence map›Paper›PMID 30545978›Full record

ReviewThe European respiratory journal2019

Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management.

Erika B Rosenzweig, Steven H Abman, Ian Adatia, Maurice Beghetti, Damien Bonnet, Sheila Haworth, D Dunbar Ivy, Rolf M F Berger

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06454838 (Exercise Capacity Muscle Oxygenation and Arterial Stiffness in Children With Pulmonary Arterial Hypertension), which is not on this map. Cited by 278 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
278citing papers in PubMed, 5 pooled it
40.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06454838 recruitingnot on this mapstarted 2024, after this paper: background citation

Exercise Capacity Muscle Oxygenation and Arterial Stiffness in Children With Pulmonary Arterial Hypertension

TypeobservationalSponsorGazi UniversityRan2024 to 2025Enrolled26ConditionsPulmonary Arterial Hypertension
3 · Its place in the literature

Who cites it

278 citing papers in PubMed, 5 syntheses or guidelines pooled it, 596 citations in OpenAlex.

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218 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Erika B RosenzweigColumbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
Steven H AbmanUniversity of Colorado, Children's Hospital Colorado, Denver, CO, USA.
Ian AdatiaGlenwood Children's Heart Clinic, Edmonton, AB, Canada.
Maurice BeghettiPediatric Cardiology Unit and Centre Universitaire de Cardiologie et Chirurgie Cardiaque Pédiatrique, University Hospitals of Geneva and Lausanne, Lausanne, Switzerland.
Damien BonnetHôpital Necker Enfants Malades, AP-HP, Université Paris Descartes, Paris, France.
Sheila HaworthUniversity College London, London, UK.
D Dunbar IvyUniversity of Colorado, Children's Hospital Colorado, Denver, CO, USA.
Rolf M F BergerCenter for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
University of Colorado Denver · USGlenrose Rehabilitation Hospital · CANew York Hospital Queens · USUniversité Paris Cité · FRUniversity College London · GBUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paediatric pulmonary arterial hypertension (PAH) shares common features of adult disease, but is associated with several additional disorders and challenges that require unique approaches. This article discusses recent advances, ongoing challenges and distinct approaches for the care of children with PAH, as presented by the Paediatric Task Force of the 6th World Symposium on Pulmonary Hypertension. We provide updates of the current definition, epidemiology, classification, diagnostics and treatment of paediatric PAH, and identify critical knowledge gaps. Several features of paediatric PAH including the prominence of neonatal PAH, especially in pre-term infants with developmental lung diseases, and novel genetic causes of paediatric PAH are highlighted. The use of cardiac catheterisation as a diagnostic modality and haemodynamic definitions of PAH, including acute vasoreactivity, are addressed. Updates are provided on issues related to utility of the previous classification system to reflect paediatric-specific aetiologies and approaches to medical and interventional management of PAH, including the Potts shunt. Although a lack of clinical trial data for the use of PAH-targeted therapy persists, emerging data are improving the identification of appropriate targets for goal-oriented therapy in children. Such data will likely improve future clinical trial design to enhance outcomes in paediatric PAH.

Indexed as

Disease ManagementAdolescentAntihypertensive AgentsChildChild, PreschoolDose-Response Relationship, DrugExercise TestHemodynamicsHumansInfantInfant, NewbornPractice Guidelines as TopicPulmonary Arterial HypertensionAntihypertensive Agents

Identifiers

PMID30545978
PMCPMC6351335
OpenAlexW2905553926

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.