ArticleJournal of magnetic resonance imaging : JMRI2019
3T chemical shift-encoded MRI: Detection of altered proximal femur marrow adipose tissue composition in glucocorticoid users and validation with magnetic resonance spectroscopy.
Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178145 (MRI of Epicardial Adipose Tissue Composition), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Development and internal validation of a noninvasive predictive model based on iron and fat measurements for pathologic risk stratification in prostate cancer.Translational andrology and urology · 2026Article
- Marrow fatty acids in osteoporosis: metabolic insights, emerging therapeutic targets.Journal of bone and mineral metabolism · 2026Review
- Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective.Journal of musculoskeletal & neuronal interactions · 2025Article
- Fatty acid composition MRI of epicardial adipose tissue: Methods and detection of proinflammatory biomarkers in ST-segment elevation myocardial infarction patients.Magnetic resonance in medicine · 2025 · on this mapArticle
- Application of proton density fat fraction imaging in risk stratification of prostate cancer.Translational andrology and urology · 2024Article
- Identification and validation of endoplasmic reticulum stress-related genes in patients with steroid-induced osteonecrosis of the femoral head.Scientific reports · 2024Article
- Imaging-based assessment of fatty acid composition in human bone marrow adipose tissue at 7 T: Method comparison and in vivo feasibility.Magnetic resonance in medicine · 2023Article
- Application of magnetic resonance image compilation (MAGiC) in the diagnosis of middle-aged and elderly women with osteoporosis.BMC medical imaging · 2023Article
- Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging.Current osteoporosis reports · 2023Review
- Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity-induced coronary microvascular disease.Magnetic resonance in medicine · 2022 · on this mapArticle
- Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water-Fat MRI.Frontiers in endocrinology · 2022Article
- Proton density fat fraction: magnetic resonance imaging applications beyond the liver.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Review
- Survey of MRI Usefulness for the Clinical Assessment of Bone Microstructure.International journal of molecular sciences · 2021Review
- Analysis of muscle, hip, and subcutaneous fat in osteoporosis patients with varying degrees of fracture risk using 3T Chemical Shift Encoded MRI.Bone reports · 2020Article
- Update on Imaging-Based Measurement of Bone Mineral Density and Quality.Current rheumatology reports · 2020Review
- MRI Assessment of Bone Marrow Composition in Osteoporosis.Current osteoporosis reports · 2020Review
- The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications.Current osteoporosis reports · 2019Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundOsteoporosis (OP) results in weak bone and can ultimately lead to fracture. Drugs such as glucocorticoids can also induce OP (glucocorticoid-induced osteoporosis [GIO]). Bone marrow adipose tissue composition and quantity may play a role in OP pathophysiology, but has not been thoroughly studied in GIO compared to primary OP. PURPOSE/HYPOTHESIS: Chemical shift-encoded (CSE) MRI allows detection of subregional differences in bone marrow adipose tissue composition and quantity in the proximal femur of GIO compared to OP subjects and has high agreement with the reference standard of magnetic resonance spectroscopy (MRS). STUDY TYPE: Prospective. SUBJECTS: In all, 18 OP and 13 GIO subjects. FIELDS STRENGTH: 3T. SEQUENCE: Multiple gradient-echo, stimulated echo acquisition mode (STEAM). ASSESSMENT: Subjects underwent CSE-MRI in the proximal femurs, and for each parametric map regions of interest (ROIs) were assessed in the femoral head (fHEAD), femoral neck (fNECK), Ward's triangle (fTRIANGLE), and the greater trochanter (GTROCH). In addition, we compared CSE-MRI against the reference standard of MRS performed in the femoral neck and Ward's triangle. STATISTICAL TESTS: Differences between OP/GIO were investigated using the Mann-Whitney nonparametric test. Bland-Altman methodology was used to assess measurement agreement between CSE-MRI and MRS.
resultsGIO compared with OP subjects demonstrated: decreased monounsaturated fat fraction (MUFA) (-2.1%, P < 0.05) in fHEAD; decreased MUFA (-3.8%, P < 0.05), increased saturated fat fraction (SFA) (5.5%, P < 0.05), and decreased DATA
conclusion3T CSE-MRI may allow reliable assessment of subregional bone marrow adipose tissue (bMAT) quantity and composition in the proximal femur in a clinically reasonable scan time. Glucocorticoids may alter the lipid profile of bMAT and potentially result in reduced bone quality. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:490-496.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.