ArticleJournal of clinical lipidology
Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal.
Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Age-dependent sex differences in cardiometabolic risk factors.Nature cardiovascular research · 2022Article
- Association between self-reported medical diagnosis of depression and metabolic syndrome in a population-based study: A propensity score-matched analysis.Nursing open · 2022Article
- Network of biomarkers and their mediation effects on the associations between regular exercise and the incidence of cardiovascular & metabolic diseases.Scientific reports · 2021Article
- Prevalence, control, and treatment of diabetes, hypertension, and high cholesterol in the Amish.BMJ open diabetes research & care · 2020Article
- Lipid profile of regular kratom (Mitragyna speciosa Korth.) users in the community setting.PloS one · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundPostprandial lipemia (PPL), defined as a prolonged or elevated rise in triglycerides that accompanies fat feeding, is a significant risk factor for coronary heart disease and associated comorbidities. The impact of PPL on coronary heart disease risk is underscored by the preponderance of each day spent in the postprandial state.
objectiveIn this study, we evaluated cross-sectionally the association between usual (ie, noninterventional) physical activity and the 6-hour triglyceride response to a standardized high-fat meal.
methodsThe high-fat meal intervention was carried out in 671 apparently healthy individuals as part of the Heredity and Phenotype Intervention Heart Study. Triglyceride levels were measured in the fasting state and during 6 hours after administration of a standardized fat challenge. We defined PPL response as the triglyceride area under the fat load curve (AUC) and measured physical activity using accelerometers that were worn continuously over a 7-day period.
resultsPhysical activity levels decreased with increasing age and were higher in men than women (both P < .001). The triglyceride AUC increased with increasing age in both men and women (both P < .001) and was also higher in men than in women (age-adjusted P = 9.2 × 10
conclusionThese results suggest that the protective benefits of physical activity on cardiovascular health may operate, at least in part, through reduction of the PPL triglyceride response.
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