ArticleJournal of diabetes investigation2019
Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection.
Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Association betweenThe Journal of international medical research · 2026Article
- Review
- Eradication ofIranian journal of microbiology · 2025Article
- Article
- Investigating the Effect of eradication ofArchives of Razi Institute · 2024Article
- Effect of Helicobacter pylori on sleeve gastrectomy and gastric microbiome differences in patients with obesity and diabetes.International journal of obesity (2005) · 2024Article
- Association of Helicobacter pylori infection with complications of diabetes: a single-center retrospective study.BMC endocrine disorders · 2024Article
- Identification of hub genes associated withWorld journal of diabetes · 2024Article
- Relationship betweenFrontiers in cellular and infection microbiology · 2023Article
- Long-term effect of the eradication of Helicobacter pylori on the hemoglobin A1c in type 2 diabetes or prediabetes patients.The Korean journal of internal medicine · 2022Article
- AcuteInfection and drug resistance · 2022Article
- Prevalence ofAdvanced biomedical research · 2020Article
- Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection.Journal of diabetes investigation · 2019Article
- Relation ofDiabetes & vascular disease researchArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
AIMS/
introductionHelicobacter pylori infection is associated with insulin resistance and glycemia in non-diabetes. However, the relationship between H. pylori infection and glycemia in diabetes remains inconclusive. Therefore, we explored the effect of H. pylori infection status and its eradication on glycemic control and antidiabetic therapy in type 2 diabetes patients. MATERIALS AND
methodsA total of 549 diabetes patients were recruited for sequential two-step approach (immunoglobulin G [IgG] serology followed by
resultsDespite no between-group difference in A1C, the "active" infection group (n = 208) had significantly more prescriptions of oral antidiabetic drug classes (2.1 ± 1.1 vs 1.8 ± 1.1, P = 0.004) and higher percentages of sulfonylurea use (67.3% vs 50.4%, P < 0.001) than the "non-active" infection group (n = 341). There were no differences in A1C and oral antidiabetic drug classes between "past" (n = 111) and "never/remote" infection groups (n = 230). Compared with the non-eradication group (n = 99), the eradication group (n = 98) had significant within-group (-0.17 ± 0.80%, P = 0.036) and between-group (-0.23 ± 0.10%, P = 0.024) improvements in A1C.
conclusionsDiabetes patients with active H. pylori infection need higher glycemic treatment intensity to achieve comparable glycemia. Furthermore, H. pylori eradication decreases A1C, and thus improves glycemic control.
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