Evidence map›Paper›PMID 30566868›Full record

ArticleCell reports2018

Paired Related Homeobox Protein 1 Regulates Quiescence in Human Oligodendrocyte Progenitors.

Jing Wang, Darpan Saraswat, Anjali K Sinha, Jessie Polanco, Karen Dietz, Melanie A O'Bara, Suyog U Pol, Hani J Shayya, Fraser J Sim

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

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  13. Leveraging gene correlations in single cell transcriptomic data.bioRxiv : the preprint server for biology · 2023
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  19. Heparanome-Mediated Rescue of Oligodendrocyte Progenitor Quiescence following Inflammatory Demyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jing WangDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Darpan SaraswatDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Anjali K SinhaNeuroscience Program, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Jessie PolancoNeuroscience Program, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Karen DietzDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Melanie A O'BaraDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Suyog U PolDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Department of Biomedical Engineering, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Hani J ShayyaDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Fraser J SimDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Neuroscience Program, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address: fjsim@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Muscarinic Receptor Type 3 Regulation of Oligodendrocyte Progenitor DifferentiationR01NS104021 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SIM, FRASER JAMES · 2018 to 2022
$1.7M
NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA016056NINDS NIH HHS R01 NS104021
6 · The paper itself

Abstract

Human oligodendrocyte progenitor cells (hOPCs) persist into adulthood as an abundant precursor population capable of division and differentiation. The transcriptional mechanisms that regulate hOPC homeostasis remain poorly defined. Herein, we identify paired related homeobox protein 1 (PRRX1) in primary PDGFαR

Indexed as

Cell CycleAnimalsBone Morphogenetic ProteinsCell Cycle CheckpointsCell DifferentiationCell MovementCell ProliferationDemyelinating DiseasesGene Expression RegulationHomeodomain ProteinsHumansInterferon-gammaKi-67 AntigenMiceMyelin SheathOligodendrocyte Precursor CellsBone Morphogenetic ProteinsHomeodomain ProteinsInterferon-gammaKi-67 AntigenPRRX1 protein, humanRNA, MessengergliahumanquiescenceRNAiRNA-seq

Identifiers

PMID30566868
PMCPMC6347430
OpenAlexW2904997010

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.