Evidence map›Paper›PMID 30567295›Full record

ArticleInternational journal of molecular sciences2018

Chih-Yuan Fang, Mien-Cheng Chen, Tzu-Hao Chang, Chia-Chen Wu, Jen-Ping Chang, Hsien-Da Huang, Wan-Chun Ho, Yi-Zhen Wang, Kuo-Li Pan, Yu-Sheng Lin and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Chih-Yuan FangDivision of Cardiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. cyfang@seed.net.tw.
Mien-Cheng ChenDivision of Cardiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. chenmien@ms76.hinet.net.
Tzu-Hao ChangGraduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan. Kevinchang@tmu.edu.tw.
Chia-Chen WuDivision of Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. maxwu02@gmail.com.
Jen-Ping ChangDivision of Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. c9112772@ms25.hinet.net.
Hsien-Da HuangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan. bryan@mail.nctu.edu.tw.ORCID 0000-0003-2857-7023
Wan-Chun HoDivision of Cardiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. erin05201982@yahoo.com.tw.
Yi-Zhen WangDivision of Cardiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. cat206206@gmail.com.
Kuo-Li PanDivision of Cardiology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. q12070@adm.cgmh.org.tw.
Yu-Sheng LinDivision of Cardiology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. dissertlin@yahoo.com.tw.
Yao-Kuang HuangDepartment of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. yaokuang@gmail.com.
Chien-Jen ChenDivision of Cardiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. cjchen@adm.cgmh.org.tw.
Wei-Chieh LeeDivision of Cardiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. leeweichieh@yahoo.com.tw.ORCID 0000-0003-0585-6134
Chang Gung University · TWChiayi Chang Gung Memorial Hospital · TWNational Yang Ming Chiao Tung University · TWTaipei Medical University · TW

Funding

Chang Gung Memorial Hospital, Taiwan grants CMRPG8F0321
6 · The paper itself

Abstract

backgroundLipid expression is increased in the atrial myocytes of mitral regurgitation (MR) patients. This study aimed to investigate key regulatory genes and mechanisms of atrial lipotoxic myopathy in MR.

methodsThe HL-1 atrial myocytes were subjected to uniaxial cyclic stretching for eight hours. Fatty acid metabolism, lipoprotein signaling, and cholesterol metabolism were analyzed by PCR assay (168 genes).

resultsThe stretched myocytes had significantly larger cell size and higher lipid expression than non-stretched myocytes (all

conclusionsThe

Indexed as

Carbon-Carbon Double Bond IsomerasesCell LineCholesterolFlow CytometryGene Expression RegulationHeart AtriaHemiterpenesHumansHydroxymethylglutaryl-CoA SynthaseLipid MetabolismLipidsLipoproteinsMitral Valve InsufficiencyMyocytes, CardiacSignal TransductionCarbon-Carbon Double Bond IsomerasesCholesterolHemiterpenesHMGCS2 protein, humanHydroxymethylglutaryl-CoA Synthaseisopentenyldiphosphate delta-isomeraseLipidsLipoproteinsatriumgeneslipidmyopathy

Identifiers

PMID30567295
PMCPMC6321625
OpenAlexW2904195324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.