Evidence map›Paper›PMID 30580682›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Vitamin K Status, Warfarin Use, and Arterial Stiffness in Heart Failure.

Zeba Hashmath, Jonathan Lee, Swetha Gaddam, Bilal Ansari, Garrett Oldland, Khuzaima Javaid, Anique Mustafa, Izzah Vasim, Scott Akers, Julio A Chirinos

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2019
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zeba HashmathFrom the Saint Vincent Hospital, Department of Internal Medicine, Worcester, MA (Z.H.).
Jonathan LeeUniversity of Pennsylvania Perelman School of Medicine, Center for Magnetic Resonance and Optical Imaging, Philadelphia (J.L., S.G., G.O., I.V., J.A.C.).
Swetha GaddamUniversity of Pennsylvania Perelman School of Medicine, Center for Magnetic Resonance and Optical Imaging, Philadelphia (J.L., S.G., G.O., I.V., J.A.C.).
Bilal AnsariHospital of the University of Pennsylvania, Philadelphia (J.L., S.G., B.A., G.O., A.M., J.A.C.).
Garrett OldlandUniversity of Pennsylvania Perelman School of Medicine, Center for Magnetic Resonance and Optical Imaging, Philadelphia (J.L., S.G., G.O., I.V., J.A.C.).
Khuzaima JavaidCorporal Michael J. Crescenz VAMC, Philadelphia, PA (S.G., G.O., K.J., I.V., S.A.).
Anique MustafaHospital of the University of Pennsylvania, Philadelphia (J.L., S.G., B.A., G.O., A.M., J.A.C.).
Izzah VasimUniversity of Pennsylvania Perelman School of Medicine, Center for Magnetic Resonance and Optical Imaging, Philadelphia (J.L., S.G., G.O., I.V., J.A.C.).
Scott AkersCorporal Michael J. Crescenz VAMC, Philadelphia, PA (S.G., G.O., K.J., I.V., S.A.).
Julio A ChirinosUniversity of Pennsylvania Perelman School of Medicine, Center for Magnetic Resonance and Optical Imaging, Philadelphia (J.L., S.G., G.O., I.V., J.A.C.).
University of Pennsylvania · USHospital of the University of Pennsylvania · USSaint Vincent Hospital · US

Funding

Efficacy of Potassium Nitrate in Heart Failure with Preserved Ejection FractionR01HL121510 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2019
$3.1M
Targeting Central Pulsatile Hemodynamics in Chronic Kidney DiseaseR56HL124073 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2015
$594k
NHLBI NIH HHS R01 HL121510NHLBI NIH HHS R56 HL124073
6 · The paper itself

Abstract

Large artery stiffening contributes to the pathophysiology of heart failure (HF) and associated comorbidities. MGP (matrix Gla-protein) is a potent inhibitor of vascular calcification. MGP activation is vitamin K-dependent. We aimed (1) to compare dp-ucMGP (dephospho-uncarboxylated MGP) levels between subjects with HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) and subjects without HF; (2) to assess the relationship between dp-ucMGP levels and arterial stiffness; and (3) to assess the relationship between warfarin use, dp-ucMGP levels, and arterial stiffness in HF. We enrolled 348 subjects with HFpEF (n=96), HFrEF (n=53), or no HF (n=199). Carotid-femoral pulse wave velocity, a measure of large artery stiffness, was measured with arterial tonometry. Dp-ucMGP was measured with ELISA. Dp-ucMGP levels were greater in both HFrEF (582 pmol/L; 95% CI, 444-721 pmol/L) and HFpEF (549 pmol/L; 95% CI, 455-643 pmol/L) compared with controls (426 pmol/L; 95% CI, 377-475 pmol/L; ANCOVA P=0.0067). Levels of dp-ucMGP were positively associated with carotid-femoral pulse wave velocity (standardized β, 0.31; 95% CI, 0.19-0.42; P<0.0001), which was also true in analyses restricted to patients with HF (standardized β, 0.34; 95% CI, 0.16-0.52; P=0.0002). Warfarin use was significantly associated with carotid-femoral pulse wave velocity (standardized β, 0.13; 95% CI, 0.004-0.26; P=0.043), but this relationship was eliminated after adjustment for dp-ucMGP. In conclusion, levels of dp-ucMGP are increased in HFpEF and HFrEF and are independently associated with arterial stiffness. Future studies should investigate whether vitamin K supplementation represents a suitable therapeutic strategy to prevent or reduce arterial stiffness in HFpEF and HFrEF.

Indexed as

Vascular StiffnessAgedCalcium-Binding ProteinsExtracellular Matrix ProteinsFemaleHeart FailureHumansMaleMatrix Gla ProteinMiddle AgedProspective StudiesPulse Wave AnalysisStroke VolumeVitamin KWarfarinCalcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla ProteinVitamin KWarfarinheart failurematrix Gla proteinvascular calcificationvitamin Kwarfarin

Identifiers

PMID30580682
PMCPMC6326852
OpenAlexW2906658270

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.