Evidence map›Paper›PMID 30580974›Full record

Trial reportThe Journal of pediatrics2019

Effects of Daily Zinc, Daily Multiple Micronutrient Powder, or Therapeutic Zinc Supplementation for Diarrhea Prevention on Physical Growth, Anemia, and Micronutrient Status in Rural Laotian Children: A Randomized Controlled Trial.

Maxwell A Barffour, Guy-Marino Hinnouho, Sengchanh Kounnavong, K Ryan Wessells, Kethmany Ratsavong, Bangone Bounheuang, Bigphone Chanhthavong, Dalaphone Sitthideth, Khanpaseuth Sengnam, Charles D Arnold and 2 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02428647 (Lao Zinc Study), which is not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428647 nacompletednot on this map

Lao Zinc Study: The Effects of Two Forms of Daily Preventive Zinc Supplementation Versus Therapeutic Zinc Supplementation for Diarrhea on Young Children's Physical Growth and Risk of New Episodes of Diarrhea

TypeinterventionalSponsorUniversity of California, DavisRan2015 to 2017Enrolled3,433ConditionsDiarrheaArmsMNP, preventive zinc supplement, therapeutic zinc supplement, preventive placebo supplement, therapeutic placebo supplement
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  16. Hemoglobins F, AInternational journal of laboratory hematology · 2020
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  20. Do Ethnicity/Caste-Based Disparities Influence Childhood Anemia in India?Journal of racial and ethnic health disparities · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Maxwell A BarffourProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA; Public Health Program, College of Health and Human Services, Missouri State University, Springfield, MO. Electronic address: mabarffour@ucdavis.edu.
Guy-Marino HinnouhoProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Sengchanh KounnavongLao Tropical and Public Health Institute (Lao TPHI), Vientiane, Laos.
K Ryan WessellsProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Kethmany RatsavongLao Tropical and Public Health Institute (Lao TPHI), Vientiane, Laos.
Bangone BounheuangLao Tropical and Public Health Institute (Lao TPHI), Vientiane, Laos.
Bigphone ChanhthavongLao Tropical and Public Health Institute (Lao TPHI), Vientiane, Laos.
Dalaphone SitthidethLao Tropical and Public Health Institute (Lao TPHI), Vientiane, Laos.
Khanpaseuth SengnamLao Tropical and Public Health Institute (Lao TPHI), Vientiane, Laos.
Charles D ArnoldProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Kenneth H BrownProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA; Nutrition and Global Development, Bill & Melinda Gates Foundation, Seattle, WA.
Sonja Y HessProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
University of California, Davis · USGates Foundation · USMissouri State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the optimal zinc supplementation strategy for improving growth and hematologic and micronutrient status in young Laotian children. STUDY

designIn total, 3407 children aged 6-23 months were randomized to receive either daily preventive zinc tablets (7 mg/d), high-zinc, low-iron micronutrient powder (10 mg/d zinc, 6 mg/d iron, and 13 other micronutrients), therapeutic zinc supplementation for diarrhea (20 mg/d for 10 days per episode), or daily placebo powder; all were followed for ~9 months. Anthropometry, hemoglobin, zinc, and iron status were assessed at baseline and endline. Analyses were by intention-to-treat, using linear and modified Poisson regression.

resultsAt baseline, mean (±SD) age was 14.2 ± 5.1 months and stunting and anemia prevalence were 37.9% and 55.6%, respectively. At endline, zinc deficiency in the preventive zinc (50.7%) and micronutrient powder (59.1%) groups were significantly lower than in the therapeutic zinc (79.2%) and control groups (78.6%; P < .001), with no impact on stunting (37.1%-41.3% across the groups, P = .37). The micronutrient powder reduced iron deficiency by 44%-55% compared with other groups (P < .001), with no overall impact on anemia (P = .14). Micronutrient powder tended to reduce anemia by 11%-16% among children who were anemic at baseline (P = .06).

conclusionsDespite improving zinc status, preventive zinc and micronutrient powder had no impact on growth. The micronutrient powder improved iron status and tended to reduce anemia among the subset of previously anemic children.

trial registrationClinicalTrials.govNCT02428647.

Indexed as

Dietary SupplementsAnemia, Iron-DeficiencyDiarrheaDouble-Blind MethodGrowth DisordersHumansInfantLaosMicronutrientsPowdersZincMicronutrientsPowdersZinc

Identifiers

PMID30580974
PMCPMC6448681
OpenAlexW2905699384

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.