Evidence map›Paper›PMID 30582229›Full record

ArticleBrain pathology (Zurich, Switzerland)2019

27-hydroxycholesterol promotes Aβ accumulation via altering Aβ metabolism in mild cognitive impairment patients and APP/PS1 mice.

Xiaona Zhang, Yuandi Xi, Huiyan Yu, Yu An, Ying Wang, Lingwei Tao, Yushan Wang, Wen Liu, Tao Wang, Rong Xiao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. IsomiR Utility in Amyotrophic Lateral Sclerosis Prognostication.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
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  11. Plasma oxysterols are associated with serum lipids and dementia risk in older women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  12. Oxysterols in Central and Peripheral Synaptic Communication.Advances in experimental medicine and biology · 2024
    Article
  13. Enzymatically Formed Oxysterols and Cell Death.Advances in experimental medicine and biology · 2024
    Review
  14. Implication of Oxysterols and Phytosterols in Aging and Human Diseases.Advances in experimental medicine and biology · 2024
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiaona ZhangSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Yuandi XiSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Huiyan YuSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Yu AnSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Ying WangSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Lingwei TaoSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Yushan WangSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Wen LiuSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Tao WangSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Rong XiaoSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.ORCID 0000-0002-0603-9518
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oxysterol 27-hydroxycholesterol (27-OHC) has been considered to play a key role in the pathogenesis of Alzheimer's disease (AD). Because β-amyloid peptide (Aβ) is the pathological hallmark of AD, the aim of this study is to verify whether 27-OHC could lead to cognitive impairment through modulating Aβ accumulation and deposition. Regulation of Aβ metabolism was explored as the pathogenic mechanism of 27-OHC. Furthermore, microRNAs (miRNAs) and their relations with 27-OHC were also detected. In present study, matched case-control study and APP/PS1 transgenic mice research were conducted. The results showed that the 27-OHC and Aβ in plasma were increased in mild cognitive impairment patients, and a slight correlation was found between 27-OHC and Aβ1-40. This relationship was also proved by the research of APP/PS1 mice. More severe learning and memory impairment and higher Aβ1-40 expression in brain and plasma were detected in the APP/PS1 mice of 27-OHC treatment group. In addition, increased amyloid plaques were also found in the hippocampus of 27-OHC-treated mice. In order to find out the mechanism of 27-OHC on regulating Aβ metabolism, the factors of Aβ production (APP, BACE1 and ADAM10), transport (LRP1 and RAGE) and elimination (NEP and IDE) were tested respectively. The gene and protein expressions of APP, BACE1 and RAGE were increased while LRP1 and IDE were decreased in the brain of 27-OHC-treated mice. At last, down-regulated expression of miRNA let-7g-5p was found after 27-OHC treatment. In conclusion, these findings suggested that excessive 27-OHC could enhance the accumulation and deposition of Aβ both in brain and blood, resulting in a severe impairment of cognition, especially in the modulation of Aβ1-40. The mechanism might be associated with the regulation of Aβ metabolism, and miRNA let-7g-5p was likely to play a vital role in this pathological process induced by 27-OHC.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsBrainCase-Control StudiesCognitive DysfunctionDisease Models, AnimalHippocampusHumansHydroxycholesterolsMemory DisordersMiceMice, Inbred C57BLMice, Transgenic27-hydroxycholesterolAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAPP protein, humanHydroxycholesterolsPeptide FragmentsPresenilin-127-hydroxycholesterolAlzheimer’s diseaseAPP/PS1 mouse modelmetabolismmild cognitive impairmentβ-amyloid peptide

Identifiers

PMID30582229
PMCPMC8028629
OpenAlexW2906559471

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.