ArticleThe Lancet. Respiratory medicine2019
DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study.
Article in The Lancet. Respiratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
126 citing papers in PubMed, 7 syntheses or guidelines pooled it, 206 citations in OpenAlex.
- Violence-Related Distress, Nasal Epithelial Gene Expression, and T17-High Asthma in Youth.Pediatric pulmonology · 2026Pooled it
- Long-Term PMAnnals of the American Thoracic Society · 2025Pooled it
- Differential gene expression in nasal airway epithelium from overweight or obese youth with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children.Pediatric pulmonology · 2021Pooled it
- A genome-wide study of DNA methylation in white blood cells and asthma in Latino children and youth.Epigenetics · 2021Pooled it
- A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.The European respiratory journal · 2021Pooled it
- Shared DNA methylation signatures in childhood allergy: The MeDALL study.The Journal of allergy and clinical immunology · 2021Pooled it
- Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age.Clinical epigenetics · 2025Trial
- Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age.Clinical epigenetics · 2024Trial
- Trial
- Violence-related distress and lung function in two longitudinal studies of youth.The European respiratory journal · 2022Trial
- Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.The Journal of allergy and clinical immunology · 2020Trial
- Nasal Epithelial Immune Signatures Are Associated With Age-Dependent Asthma Trajectories in Early Life.Allergy · 2026Observational
- Precision medicine to diagnose asthma in preschool children: comparison of clinical scores, lung function, biomarkers, and genetic tests.Paediatric respiratory reviews · 2026Review
- Pathway-level epigenetic modeling illuminates the methylation architecture to asthma risk across tissues.Epigenetics & chromatin · 2026Article
- eQTM (expression quantitative trait methylation) Atlas: a comprehensive resource of over 11 million DNA methylation-gene expression associations through across 11 tissues and 4 diseases.bioRxiv : the preprint server for biology · 2026Article
- Persistent exposure to second-hand smoke and asthma endotypes in a study of Puerto Rican youth.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Obesity, Air Pollution, and Epigenetic Modifications as Risk Factors for Asthma Phenotypes.International journal of molecular sciences · 2026Review
- Transcriptome-wide association study of sex effects identifies sex-specific nasal epithelial gene expression profiles for total IgE.The Journal of allergy and clinical immunology · 2026Article
- Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.Science advances · 2026Article
66 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundEpigenetic mechanisms could alter the airway epithelial barrier and ultimately lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that are associated with-and could accurately classify-atopy and atopic asthma in school-aged children.
methodsWe did a genome-wide study of DNA methylation in nasal epithelium and atopy or atopic asthma in 483 Puerto Rican children aged 9-20 years, recruited using multistage probability sampling. Atopy was defined as at least one positive IgE (≥0·35 IU/mL) to common aeroallergens, and asthma was defined as a physician's diagnosis plus wheeze in the previous year. Significant (false discovery rate p<0·01) methylation signals were correlated with gene expression, and top CpGs were validated by pyrosequencing. We then replicated our top methylation findings in a cohort of 72 predominantly African American children, and in 432 children from a European birth cohort. Next, we tested classification models based on nasal methylation for atopy or atopic asthma in all cohorts.
findingsDNA methylation profiles were markedly different between children with (n=312) and without (n=171) atopy in the Puerto Rico discovery cohort, recruited from Feb 12, 2014, until May 8, 2017. After adjustment for covariates and multiple testing, we found 8664 differentially methylated CpGs by atopy, with false discovery rate-adjusted p values ranging from 9·58 × 10
interpretationWe identified specific methylation profiles in airway epithelium that are associated with atopy and atopic asthma in children, and a nasal methylation panel that could classify children by atopy or atopic asthma. Our findings support the feasibility of using the nasal methylome for future clinical applications, such as predicting the development of asthma among wheezing infants.
fundingUS National Institutes of Health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.