Evidence map›Paper›PMID 30591656›Full record

Trial reportNutrients2018

Impact of Two Forms of Daily Preventive Zinc or Therapeutic Zinc Supplementation for Diarrhea on Hair Cortisol Concentrations Among Rural Laotian Children: A Randomized Controlled Trial.

Guy-Marino Hinnouho, Robin M Bernstein, Maxwell A Barffour, Charles D Arnold, K Ryan Wessells, Kethmany Ratsavong, Bangone Bounheuang, Sengchanh Kounnavong, Sonja Y Hess

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02428647 (Lao Zinc Study), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428647 nacompletednot on this map

Lao Zinc Study: The Effects of Two Forms of Daily Preventive Zinc Supplementation Versus Therapeutic Zinc Supplementation for Diarrhea on Young Children's Physical Growth and Risk of New Episodes of Diarrhea

TypeinterventionalSponsorUniversity of California, DavisRan2015 to 2017Enrolled3,433ConditionsDiarrheaArmsMNP, preventive zinc supplement, therapeutic zinc supplement, preventive placebo supplement, therapeutic placebo supplement
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Hair collection protocol in 12-month-old infants.Comprehensive psychoneuroendocrinology · 2024
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Guy-Marino HinnouhoProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA 95616, USA. gmhinnouho@ucdavis.edu.ORCID 0000-0001-8079-9702
Robin M BernsteinDepartment of Anthropology, University of Colorado, Boulder, CO 80309, USA. robin.bernstein@colorado.edu.
Maxwell A BarffourProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA 95616, USA. mabarffour@ucdavis.edu.
Charles D ArnoldProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA 95616, USA. cdarnold@ucdavis.edu.ORCID 0000-0001-6510-3172
K Ryan WessellsProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA 95616, USA. krwessells@ucdavis.edu.ORCID 0000-0002-5485-7144
Kethmany RatsavongLao Tropical and Public Health Institute, Ban Kaognot, Sisattanack District, Vientiane 01030, Laos. kethmany.ratsavong@gmail.com.
Bangone BounheuangLao Tropical and Public Health Institute, Ban Kaognot, Sisattanack District, Vientiane 01030, Laos. bangonbounheuang@gmail.com.
Sengchanh KounnavongLao Tropical and Public Health Institute, Ban Kaognot, Sisattanack District, Vientiane 01030, Laos. sengchanhkounnavong@hotmail.com.
Sonja Y HessProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA 95616, USA. syhess@ucdavis.edu.ORCID 0000-0002-4661-277X
University of California, Davis · USMissouri State University · USUniversity of Colorado Boulder · US

Funding

Bill and Melinda Gates Institute for Population and Reproductive Health OPP1134272Mathile Institute for the Advancement of Human Nutrition and Nutrition International 10-1347-UCALIF-07
6 · The paper itself

Abstract

Zinc supplementation has been shown to reduce the morbidity burden among young children, and may reduce chronic stress. Hair cortisol has been promoted as an indicator of chronic stress. We assessed the impact of different strategies for delivering supplementary zinc on hair cortisol concentrations (HCC) in young Laotian children and examined risk factors associated with HCC. In a randomized double-blind controlled trial (NCT02428647), children aged 6⁻23 mo were randomized to one of four intervention groups and followed for ~36 weeks: daily preventive zinc (PZ) tablets (7 mg/day), daily multiple micronutrient powder (MNP) sachets (containing 10 mg zinc and 14 other micronutrients), therapeutic zinc (TZ) supplements for diarrhea treatment (20 mg/day for 10 days) or daily placebo powder. HCC of 512 children was assessed at baseline and endline. ANCOVA and linear regression models were used to assess group differences in HCC and to examine the risk factors associated with HCC, respectively. At enrollment, mean HCC was 28.8 ± 43.9 pg/mg. In models adjusted for age at enrollment, health district, and baseline HCC there was no overall effect of the interventions on endline HCC and change in HCC. When controlling for additional predetermined covariates, there was a marginally significant effect on change in HCC (

Indexed as

DiarrheaDietary SupplementsDouble-Blind MethodFemaleHairHumansHydrocortisoneInfantLaosMaleRisk FactorsRural PopulationStress, PhysiologicalZincHydrocortisoneZincchronic stresshair cortisolLao PDRmicronutrient powderMNPyoung childrenzinc supplementation

Identifiers

PMID30591656
PMCPMC6356851
OpenAlexW2906403701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.