Evidence map›Paper›PMID 30591971›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2019

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats.

Yukiko Shimizu, Rieko Yanobu-Takanashi, Kenta Nakano, Kenji Hamase, Toshiaki Shimizu, Tadashi Okamura

Open access · hybridAbstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis.International journal of molecular sciences · 2021
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yukiko ShimizuDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine (NCGM), 1-21-1 Toyama, Shinjyuku-ku, Tokyo, 162-8655, Japan.
Rieko Yanobu-TakanashiDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine (NCGM), 1-21-1 Toyama, Shinjyuku-ku, Tokyo, 162-8655, Japan.
Kenta NakanoDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine (NCGM), 1-21-1 Toyama, Shinjyuku-ku, Tokyo, 162-8655, Japan.
Kenji HamaseGraduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Toshiaki ShimizuDepartment of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Tadashi OkamuraDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine (NCGM), 1-21-1 Toyama, Shinjyuku-ku, Tokyo, 162-8655, Japan. okamurat@ri.ncgm.go.jp.
National Center for Global Health and Medicine · JPJuntendo University · JPKyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Long-Evans Agouti (LEA/Tohm) rat has recently been established as a new rat model of type 2 diabetes. The onset of diabetes mellitus was observed only in male LEA/Tohm rats; however, urinary glucose appeared before the onset of diabetes. To clarify the genetic basis of urinary glucose, we performed genetic linkage analysis using (BN × LEA) F

Indexed as

Sequence DeletionAllelesAmino Acid SequenceAmino Acid Transport Systems, NeutralAnimalsBiomarkersCystineDNA Mutational AnalysisFibroblastsGenetic LinkageGenotypeKidney TubulesMutationPhenotypeQuantitative Trait LociRatsAmino Acid Transport Systems, NeutralBiomarkersCystine

Identifiers

PMID30591971
PMCPMC6397714
OpenAlexW2906922355

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.