Evidence map›Paper›PMID 30596106›Full record

ArticleJournal of immunology research2018

Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer.

Hyun Ju Lee, Janice M Bahr, Pincas Bitterman, Sanjib Basu, Sameer Sharma, Jacques S Abramowicz, Animesh Barua

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hyun Ju LeeCollege of Pharmacy, University of Illinois at Chicago, IL, USA.
Janice M BahrDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, IL, USA.
Pincas BittermanDepartment of Pathology, Rush University Medical Center, Chicago, IL, USA.
Sanjib BasuDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, USA.
Sameer SharmaDepartment of Obstetrics and Gynecology, Rush University Medical Center, Chicago, IL, USA.
Jacques S AbramowiczDepartment of Obstetrics and Gynecology, University of Chicago, IL, USA.
Animesh BaruaDepartment of Pathology, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0003-4891-0161
Rush University Medical Center · USUniversity of Chicago · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Ashwagandha supplementation enhances ovarian tumoricidal activity of NK cellsR21CA187309 · NCI · RUSH UNIVERSITY MEDICAL CENTER · PI BARUA, ANIMESH · 2015 to 2016
$386k
NCI NIH HHS R21 CA187309
6 · The paper itself

Abstract

Chronic inflammation and long-standing oxidative stress are potential predisposing factors for developing malignancies, including ovarian cancer (OVCA). Information on the association of ovarian chronic abnormal conditions, including polycystic ovarian syndrome (PCOS), with the development of OVCA is unknown. The goal of this study was to examine if polycystic ovarian conditions are associated with OVCA development. In the exploratory study, 3-4-year-old laying hens were randomly selected and examined for the presence of polycystic ovaries with cancer (PCOC). In the prospective study, hens were monitored by ultrasound scanning to detect the incidence of a polycystic ovaries and subsequent development of OVCA. Tissues from normal ovaries and PCOC were examined for macrophage infiltration, expression of interleukin-16, and superoxide dismutase 2. The exploratory study detected spontaneous PCOC at early and late stages in hens. PCOC in hens were accompanied with influx of macrophages (17.33 ± 2.26 in PCOC at the early stage and 24.24 ± 2.5 in PCOC at the late stage in 20 mm

Indexed as

AnimalsCarcinogenesisCell MovementChickensDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticHumansInterleukin-16MacrophagesOvarian NeoplasmsOvaryPolycystic Ovary SyndromeRisk FactorsSuperoxide DismutaseSuperoxide Dismutase 2Interleukin-16Superoxide DismutaseSuperoxide Dismutase 2

Identifiers

PMID30596106
PMCPMC6286744
OpenAlexW2900470152

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.