ReviewInternational journal of molecular sciences2018
The Effects of Systemic and Local Acidosis on Insulin Resistance and Signaling.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.Nutrients · 2026Trial
- Acid-Base Dysregulation Links Aging Metabolism to Frailty.Aging cell · 2026Article
- Chronic NHScientific reports · 2026Article
- Diabetes control in m.3243 A > G carriers requires comprehensive consideration.Acta diabetologica · 2026Article
- Atypical endocrine manifestations in Gordon syndrome caused by CUL3 mutation: a case report.Frontiers in medicine · 2026Article
- Lethality is local, but survival is systemic: Temporal and multi-organ responses to chlorine gas exposure in a murine model.Current research in toxicology · 2026Article
- Association Between Albumin-Corrected Anion Gap and Prevalent Prediabetes or Diabetes Mellitus: A Cross-Sectional Analysis of NHANES 2005-2010.Journal of diabetes research · 2026Article
- Fat deposition and growth performance in broiler chickens are diversely influenced by maize or wheat following dietary crude protein reductions plausibly involving insulin.Journal of animal science and biotechnology · 2025Review
- Association Between Dietary Acid Load and Excess Weight in Adults: A Cross-Sectional Study.Nutrients · 2025Article
- A perception that the feed grain basis of reduced-crude protein diets modifies the anabolic impact of insulin on the growth performance of broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Preliminary Study of Differential circRNA Expression and Investigation of circRNA-miRNA-mRNA Competitive Endogenous Network in Rumen Acidosis of Holstein Cattle.Animals : an open access journal from MDPI · 2025Article
- Effects of Preanhepatic Glucose-Insulin Infusion on Metabolic and Hemodynamic Outcomes in Liver Transplantation: A Randomized Clinical Trial : Preanhepatic Glucose-Insulin Infusion and Liver Transplantation.Galen medical journal · 2025Article
- Article
- Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.Scientific reports · 2024Article
- Hidden chronic metabolic acidosis of diabetes type 2 (CMAD): Clues, causes and consequences.Reviews in endocrine & metabolic disorders · 2023Review
- Combined Intake of Fish Oil and D-Fagomine Prevents High-Fat High-Sucrose Diet-Induced Prediabetes by Modulating Lipotoxicity and Protein Carbonylation in the Kidney.Antioxidants (Basel, Switzerland) · 2023Article
- Investigating the Ischaemic Phase of Skin NADH Fluorescence Dynamics in Recently Diagnosed Primary Hypertension: A Time Series Analysis.Journal of clinical medicine · 2023Article
- Associations of the Serum Total Carbon Dioxide Level with Long-Term Clinical Outcomes in Sepsis Survivors.Infectious diseases and therapy · 2023Article
- Insulin Resistance and Urolithiasis as a Challenge for a Dietitian.International journal of environmental research and public health · 2022Review
- Impact of the inspiratory oxygen fraction on the cardiac output during jugulo-femoral venoarterial extracorporeal membrane oxygenation in the rat.BMC cardiovascular disorders · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most pathological conditions that cause local or systemic acidosis by overcoming the buffering activities of body fluids overlap with those diseases that are characterized by glucose metabolic disorders, including diabetes mellitus, inflammation, and cancer. This simple observation suggests the existence of a strong relationship between acidosis and insulin metabolism or insulin receptor signaling. In this review, we summarized the current knowledge on the activity of insulin on the induction of acidosis and, vice versa, on the effects of changes of extracellular and intracellular pH on insulin resistance. Insulin influences acidosis by promoting glycolysis. Although with an unclear mechanism, the lowering of pH, in turn, inhibits insulin sensitivity or activity. In addition to ketoacidosis that is frequently associated with diabetes, other important and more complex factors are involved in this delicate feedback mechanism. Among these, in this review we discussed the acid-mediated inhibiting effects on insulin binding affinity to its receptor, on glycolysis, on the recycling of glucose transporters, and on insulin secretion via transforming growth factor β (TGF-β) activity by pancreatic β-cells. Finally, we revised current data available on the mutual interaction between insulin signaling and the activity of ion/proton transporters and pH sensors, and on how acidosis may enhance insulin resistance through the Nuclear Factor kappa B (NF-κB) inflammatory pathway.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.