Evidence map›Paper›PMID 30605264›Full record

ReviewAdvanced healthcare materials2019

Engineering Immune Tolerance with Biomaterials.

Joshua M Gammon, Christopher M Jewell

Open access · greenAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Review
  3. Immunometabolism of Liver Xenotransplantation and Prospective Solutions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Unlocking Transplant Tolerance with Biomaterials.Advanced healthcare materials · 2025
    Review
  5. Article
  6. Synthetic organic materials for targeting immunotherapies to lymph nodes.Chemistry of materials : a publication of the American Chemical Society · 2024
    Article
  7. Article
  8. Tailoring biomaterials for vaccine delivery.Journal of nanobiotechnology · 2024
    Review
  9. Review
  10. Article
  11. Emerging strategies for nanomedicine in autoimmunity.Advanced drug delivery reviews · 2024
    Review
  12. Vaccines for immune tolerance against autoimmune disease.Advanced drug delivery reviews · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Joshua M GammonFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive RM 5110, College Park, MD, 20742, USA.
Christopher M JewellFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive RM 5110, College Park, MD, 20742, USA.ORCID 0000-0002-6668-6928
University of Maryland, Baltimore · USUniversity of Maryland, College Park · US

Funding

Harnessing biomaterials to study the link between local lymph node function and systemic toleranceR01EB026896 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI JEWELL, CHRISTOPHER M · 2018 to 2021
$1.5M
Tunable Assembly of Regulatory Immune Signals to Promote Myelin-specific ToleranceI01BX003690 · VA · BALTIMORE VA MEDICAL CENTER · PI Christopher M Jewell · 2017 to 2026
–
BLRD VA I01 BX003690Damon Runyon Foundation DRR3415NIBIB NIH HHS R01 EB026896NSF CAREER 1351688
6 · The paper itself

Abstract

Autoimmune diseases, rejection of transplanted organs and grafts, chronic inflammatory diseases, and immune-mediated rejection of biologic drugs impact a large number of people across the globe. New understanding of immune function is revealing exciting opportunities to help tackle these challenges by harnessing-or correcting-the specificity of immune function. However, realizing this potential requires precision control over the interaction between regulatory immune cues, antigens attacked during inflammation, and the tissues where these processes occur. Engineered materials-such as polymeric and lipid particles, scaffolds, and inorganic materials-offer powerful features that can help to selectively regulate immune function during disease without compromising healthy immune functions. This review highlights some of the exciting developments to leverage biomaterials as carriers, depots, scaffolds-and even as agents with intrinsic immunomodulatory features-to promote immunological tolerance.

Indexed as

Autoimmune DiseasesBioengineeringImmune ToleranceImmunotherapyAnimalsBiocompatible MaterialsHumansBiocompatible Materialsbiomaterialsimmunology and autoimmunitymicroparticles and nanoparticlesnanotechnologyscaffoldstolerancevaccine and immunotherapy

Identifiers

PMID30605264
PMCPMC6384133
OpenAlexW2906825220

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.