SynthesisJournal of assisted reproduction and genetics2019
Testosterone therapy for women with poor ovarian response undergoing IVF: a meta-analysis of randomized controlled trials.
Synthesis in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction.The Cochrane database of systematic reviews · 2024Pooled it
- Transdermal testosterone gel vs placebo in women with diminished ovarian reserve prior to in vitro fertilization: a randomized, clinical trial.Nature communications · 2026Trial
- Effects of Testosterone on Cumulus Cells Gene Expression in Patients with Diminished Ovarian Reserve.Reproductive sciences (Thousand Oaks, Calif.) · 2025Trial
- Improvement of Pregnancy Rate and Live Birth Rate in Poor Ovarian Responders by Intraovarian Administration of Autologous Menstrual Blood Derived- Mesenchymal Stromal Cells: Phase I/II Clinical Trial.Stem cell reviews and reports · 2020Trial
- Androgenicity and fertility treatment in women with unexplained infertility.Fertility and sterility · 2020Trial
- Polymorphism of theLife (Basel, Switzerland) · 2026Article
- Identifying cycle-specific predictive factors for clinical pregnancy after recurrent implantation failure: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
- Considerations of Fertility in Elite Sportswomen: A Narrative Review.BJOG : an international journal of obstetrics and gynaecology · 2026Review
- Article
- Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients.Scientific reports · 2025Article
- The effect of methyltestosterone on in vitro fertilization outcomes: A randomized clinical trial on patients with low ovarian response.Clinical and experimental reproductive medicine · 2024Article
- Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy?Frontiers in endocrinology · 2024Article
- The effects of intraovarian injection of autologous menstrual blood-derived mesenchymal stromal cells on pregnancy outcomes in women with poor ovarian response.Stem cell research & therapy · 2023Article
- Salt-inducible kinases regulate androgen synthesis in theca cells by enhancing CREB signaling.Molecular and cellular endocrinology · 2023Article
- Androgen signalling in the ovaries and endometrium.Molecular human reproduction · 2023Review
- Prenatal Origins of Endometriosis Pathology and Pain: Reviewing the Evidence of a Role for Low Testosterone.Journal of pain research · 2023Article
- Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review.Acta medica academica · 2022Review
- Resveratrol Treatment Induces Mito-miRNome Modification in Follicular Fluid from Aged Women with a Poor Prognosis for In Vitro Fertilization Cycles.Antioxidants (Basel, Switzerland) · 2022Article
- Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present systematic review and meta-analysis was to summarize evidence on the effectiveness of testosterone supplementation for poor ovarian responders (POR) on IVF outcomes. The primary outcome was live birth rate (LBR); secondary outcomes were clinical pregnancy rate (CPR), miscarriage rate (MR), total and MII oocytes, and total embryos.
methodsThis meta-analysis of randomized controlled trials (RCTs) evaluates the effects of testosterone administration before/during COS compared with a control group in patients defined as POR. The primary outcome was live birth rate (LBR); secondary outcomes were clinical pregnancy rate (CPR), miscarriage rate (MR), total and MII oocytes, and total embryos. Pooled results were expressed as risk ratio (RR) or mean differences (MD) with 95% confidence interval (95% CI). Sources of heterogeneity were investigated through sensitivity and subgroup analysis. All analyses were performed by using the random-effects model.
resultsWomen receiving testosterone showed higher LBR (RR 2.29, 95% CI 1.31-4.01, p = 0.004), CPR (RR 2.32, 95% CI 1.47-3.64, p = 0.0003), total oocytes (MD = 1.28 [95% CI 0.83, 1.73], p < 0.00001), MII oocytes (MD = 0.96 [95% CI 0.28, 1.65], p = 0.006), and total embryos (MD = 1.17 [95% CI 0.67, 1.67], p < 0.00001) in comparison to controls, with no difference in MR (p = ns). Sensitivity and subgroup analysis did not provide statistical changes to the pooled results.
conclusionsTestosterone therapy seems promising to improve the success at IVF in POR patients. Further RCTs with rigorous methodology and inclusion criteria are still mandatory.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.