Evidence map›Paper›PMID 30612279›Full record

ArticleNeurotoxicity research2019

Effects of Preweaning Manganese in Combination with Adult Striatal Dopamine Lesions on Monoamines, BDNF, TrkB, and Cognitive Function in Sprague-Dawley Rats.

Rebecca A Bailey, Arnold Gutierrez, Tara L Kyser, Ann M Hemmerle, Jillian R Hufgard, Kim B Seroogy, Charles V Vorhees, Michael T Williams

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Scientific opinion on the tolerable upper intake level for manganese.EFSA journal. European Food Safety Authority · 2023
    Article
  2. Article
  3. Article
  4. Review
  5. Early Postnatal Manganese Exposure Reduces Rat Cortical and Striatal Biogenic Amine Activity in Adulthood.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rebecca A BaileyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Arnold GutierrezDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Tara L KyserNeuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
Ann M HemmerleDepartment of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
Jillian R HufgardDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Kim B SeroogyNeuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
Charles V VorheesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Michael T WilliamsDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. Michael.Williams@cchmc.org.ORCID http://orcid.org/0000-0001-9841-9683
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · US

Funding

National Institute of Environmental Health Sciences T32 007051
6 · The paper itself

Abstract

Manganese (Mn) is an essential nutrient especially during development, but Mn overexposure (MnOE) produces long-term cognitive deficits. Evidence of long-term changes in dopamine in the neostriatum was found in rats from developmental MnOE previously. To examine the relationship between MnOE and dopamine, we tested whether the effects of developmental MnOE would be exaggerated by dopamine reductions induced by 6-hydroxydopamine (6-OHDA) neostriatal infusion when the rats were adults. The experiment consisted of four groups of females and males: Vehicle/Sham, MnOE/Sham, Vehicle/6-OHDA, and MnOE/6-OHDA. Both MnOE/Sham and Vehicle/6-OHDA groups displayed egocentric and allocentric memory deficits, whereas MnOE+6-OHDA had additive effects on spatial memory in the Morris water maze and egocentric learning in the Cincinnati water maze. 6-OHDA reduced dopamine in the neostriatum and nucleus accumbens, reduced norepinephrine in the hippocampus, reduced TH+ cells and TrkB and TH expression in the substantia nigra pars compacta (SNpc), but increased TrkB in the neostriatum. MnOE alone had no effect on monoamines or TrkB in the neostriatum or hippocampus but reduced BDNF in the hippocampus. A number of sex differences were noted; however, only a few significant interactions were found for MnOE and/or 6-OHDA exposure. These data further implicate dopamine and BDNF in the cognitive deficits arising from developmental MnOE.

Indexed as

CognitionAnimalsBrainBrain-Derived Neurotrophic FactorCognitive DysfunctionDopamineFemaleMaleManganeseMaternal Nutritional Physiological PhenomenaMemory DisordersNorepinephrineOxidopamineParkinsonian DisordersRandom AllocationRats, Sprague-DawleyBdnf protein, ratBrain-Derived Neurotrophic FactorDopamineManganeseNorepinephrineNtrk2 protein, ratOxidopamineReceptor, trkB6-HydroxydopamineAllocentric learning and memoryCincinnati water mazeDevelopmentEgocentric learningManganeseMorris water mazeNeurotrophins

Identifiers

PMID30612279
OpenAlexW2906970126

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.