Trial reportArthritis & rheumatology (Hoboken, N.J.)2019
The Efficacy of a Lateral Wedge Insole for Painful Medial Knee Osteoarthritis After Prescreening: A Randomized Clinical Trial.
Trial report in Arthritis & rheumatology (Hoboken, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update.Annals of the rheumatic diseases · 2024Guideline
- Trial
- Personalised gait retraining for medial compartment knee osteoarthritis: a randomised controlled trial.The Lancet. Rheumatology · 2025Trial
- A Study on the Effects of Lateral-Wedge Insoles on Plantar-Pressure Pattern for Medial Knee Osteoarthritis Using the Wearable Sensing Insole.Sensors (Basel, Switzerland) · 2022Trial
- Immediate and Mid-Long-Term Effects of Foot Orthoses on Gait Biomechanics and Clinical Characteristics in Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.Annals of biomedical engineering · 2026Review
- 3D-printed shoe soles with structural properties towards reducing knee adduction moments during walking.Frontiers in bioengineering and biotechnology · 2026Article
- Effects of Massage on Pain, Muscle Co-Contraction, and Knee Loading in Medial Knee Osteoarthritis: A Randomized Controlled Trial Protocol.Journal of pain research · 2026Article
- Therapeutic Footwear for Medial Knee Osteoarthritis: Individualizing Midsole Stiffness Enhances Intended Kinetic Changes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- The influence of knee position during static calibration trials on evaluation of knee loading during gait in individual with medial knee osteoarthritis.Scientific reports · 2024Article
- Evidence-Based Review of Nonsurgical Treatments for Knee and Hip Osteoarthritis.European journal of rheumatology · 2024Article
- Clinically-accessible and laboratory-derived predictors of biomechanical response to standalone and supported lateral wedge insoles in people with knee osteoarthritis.Journal of foot and ankle research · 2023Article
- OpenCap: Human movement dynamics from smartphone videos.PLoS computational biology · 2023Article
- Kinematic effects of lateral wedged insoles in patients with medial knee osteoarthritis.Journal of physical therapy science · 2023Article
- Walking with Different Insoles Changes Lower-Limb Biomechanics Globally in Patients with Medial Knee Osteoarthritis.Journal of clinical medicine · 2023Article
- Effects of three-dimensional image based insole for healthy volunteers: a pilot clinical trial.Translational and clinical pharmacology · 2023Article
- Association of medial arch support of foot orthoses with knee valgus angle at initial contact during cutting maneuvers in female athletes: a controlled laboratory study.BMC sports science, medicine & rehabilitation · 2022Article
- Personalization improves the biomechanical efficacy of foot progression angle modifications in individuals with medial knee osteoarthritis.Journal of biomechanics · 2022Article
- Changes in the Kinematics of Midfoot and Rearfoot Joints with the Use of Lateral Wedge Insoles.Journal of clinical medicine · 2022Article
- Changes in foot progression angle during gait reduce the knee adduction moment and do not increase hip moments in individuals with knee osteoarthritis.Journal of biomechanics · 2022Article
- Muscle coordination retraining inspired by musculoskeletal simulations reduces knee contact force.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveLateral wedge shoe insoles decrease medial knee loading, but trials have shown no effect on pain in medial knee osteoarthritis (OA). However, loading effects of insoles are inconsistent, and they can increase patellofemoral loading. We undertook this study to investigate the hypothesis that insoles would reduce pain in preselected patients.
methodsAmong patients with painful medial knee OA, we excluded those with patellofemoral OA and those with a pain rating of <4 of a possible 10. We further excluded participants who, in a gait analysis using lateral wedges, did not show at least a 2% reduction in knee adduction moment (KAM), compared to wearing their shoes and a neutral insole. We then randomized subjects to lateral wedge versus neutral insole for 8-week periods, separated by an 8-week washout. The primary outcome measure was knee pain (0-10 scale) during the past week, and secondary outcome measures included activity pain and pain rated in the Knee Injury and Osteoarthritis Outcome Score questionnaire. We carried out mixed model analyses adjusted for baseline pain.
resultsOf 83 participants, 21 (25.3%) were excluded from analysis because of insufficient reduction in KAM. In the 62 patients included in analysis, the mean ± SD age was 64.2 ± 9.1 years, and 37.1% were women. Lateral wedge insoles produced a greater reduction in knee pain than neutral insoles (mean difference of 0.7 on 0-10 scale [95% confidence interval 0.1, 1.2]) (P = 0.02). Findings for secondary outcome measures were mixed.
conclusionIn participants prescreened to eliminate those with patellofemoral OA and biomechanical nonresponders, lateral wedge insoles reduced knee pain, but the effect of treatment was small and is likely of clinical significance in only a minority of patients. Targeting patients may identify those who respond to this treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.