Evidence map›Paper›PMID 30622158›Full record

ReviewClinical science (London, England : 1979)2019

Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.

Andrew M South, Hossam A Shaltout, Lisa K Washburn, Alexa S Hendricks, Debra I Diz, Mark C Chappell

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical science (London, England : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04752293 (Pediatric Hypertension and the Renin-Angiotensin SystEm), which is not on this map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04752293 recruitingnot on this mapstarted 2021, after this paper: background citation

Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage

TypeobservationalSponsorWake Forest University Health SciencesRan2021 to 2026Enrolled125ConditionsHypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Diagnostic and therapeutic precision in cardiovascular diseases in the neonatal intensive care.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  7. Cardiovascular Health Starts in the Womb.Hypertension (Dallas, Tex. : 1979) · 2024
    Review
  8. Article
  9. Systemic hemodynamics and pediatric lung disease: mechanistic links and therapeutic relevance.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  10. Review
  11. Alternative Renin-Angiotensin System.Hypertension (Dallas, Tex. : 1979) · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Pathomechanisms of Prenatally Programmed Adult Diseases.Antioxidants (Basel, Switzerland) · 2023
    Review
  18. Review
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew M SouthDepartment of Pediatrics, Section of Nephrology, Wake Forest School of Medicine, 526 Vine Street, Winston Salem, NC 27157, U.S.A.
Hossam A ShaltoutCardiovascular Sciences Center, Wake Forest School of Medicine, 526 Vine Street, Winston Salem, NC 27157, U.S.A.
Lisa K WashburnDepartment of Pediatrics, Section of Nephrology, Wake Forest School of Medicine, 526 Vine Street, Winston Salem, NC 27157, U.S.A.
Alexa S HendricksCardiovascular Sciences Center, Wake Forest School of Medicine, 526 Vine Street, Winston Salem, NC 27157, U.S.A.ORCID 0000-0003-0791-6890
Debra I DizCardiovascular Sciences Center, Wake Forest School of Medicine, 526 Vine Street, Winston Salem, NC 27157, U.S.A.
Mark C ChappellCardiovascular Sciences Center, Wake Forest School of Medicine, 526 Vine Street, Winston Salem, NC 27157, U.S.A. mchappel@wakehealth.edu.ORCID 0000-0001-5869-6037

Funding

The Impact of Antenatal Steroid Exposure on the Intrarenal Renin-Angiotensin SystP01HD047584 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2005 to 2005
$908k
Intramural NIH HHS Z01 HD008843NCATS NIH HHS UL1 TR001420NICHD NIH HHS P01 HD047584NICHD NIH HHS R21 HD084227NINDS NIH HHS F99 NS105212
6 · The paper itself

Abstract

Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious worldwide health concern and a significant healthcare burden. As the majority of hypertension has an unknown etiology, considerable research efforts in both experimental models and human cohorts has focused on the premise that alterations in the fetal and perinatal environment are key factors in the development of hypertension in children and adults. The exact mechanisms of how fetal programming events increase the risk of hypertension and cardiovascular disease are not fully elaborated; however, the focus on alterations in the biochemical components and functional aspects of the renin-angiotensin (Ang) system (RAS) has predominated, particularly activation of the Ang-converting enzyme (ACE)-Ang II-Ang type 1 receptor (AT

Indexed as

Blood PressureRenin-Angiotensin SystemAngiotensin IAnimalsBrainCardiovascular SystemFemaleFetusHumansHypertensionKidneyMalePeptide FragmentsPlacentaPregnancyPremature BirthAngiotensin Iangiotensin I (1-7)MAS1 protein, humanPeptide FragmentsProto-Oncogene MasProto-Oncogene ProteinsReceptors, G-Protein-CoupledACEangiotensin-(1-7)angiotensin converting enzyme 2fetal programming

Identifiers

PMID30622158
PMCPMC6716381

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.