Evidence map›Paper›PMID 30623647›Full record

ReviewChemical reviews2019

Computational Modeling of Realistic Cell Membranes.

Siewert J Marrink, Valentina Corradi, Paulo C T Souza, Helgi I Ingólfsson, D Peter Tieleman, Mark S P Sansom

Abstract readReview
In one paragraph

Review in Chemical reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 296 papers.

0numbers the graph read from it
0cells of the map it votes in
296citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

296 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Sketching microprotein portraits.Protein science : a publication of the Protein Society · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Lipid-Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Compartment-guided assembly of large-scale molecular models with Bentopy.Protein science : a publication of the Protein Society · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

236 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siewert J MarrinkGroningen Biomolecular Sciences and Biotechnology Institute & Zernike Institute for Advanced Materials , University of Groningen , Nijenborgh 7 , 9747 AG Groningen , The Netherlands.ORCID 0000-0001-8423-5277
Valentina CorradiCentre for Molecular Simulation and Department of Biological Sciences , University of Calgary , 2500 University Drive NW , Calgary , Alberta T2N 1N4 , Canada.
Paulo C T SouzaGroningen Biomolecular Sciences and Biotechnology Institute & Zernike Institute for Advanced Materials , University of Groningen , Nijenborgh 7 , 9747 AG Groningen , The Netherlands.
Helgi I IngólfssonBiosciences and Biotechnology Division, Physical and Life Sciences Directorate , Lawrence Livermore National Laboratory , 7000 East Avenue , Livermore , California 94550 , United States.
D Peter TielemanCentre for Molecular Simulation and Department of Biological Sciences , University of Calgary , 2500 University Drive NW , Calgary , Alberta T2N 1N4 , Canada.
Mark S P SansomDepartment of Biochemistry , University of Oxford , South Parks Road , Oxford OX1 3QU , U.K.ORCID 0000-0001-6360-7959

Funding

Biotechnology and Biological Sciences Research Council BB/R00126X/1CIHRWellcome Trust
6 · The paper itself

Abstract

Cell membranes contain a large variety of lipid types and are crowded with proteins, endowing them with the plasticity needed to fulfill their key roles in cell functioning. The compositional complexity of cellular membranes gives rise to a heterogeneous lateral organization, which is still poorly understood. Computational models, in particular molecular dynamics simulations and related techniques, have provided important insight into the organizational principles of cell membranes over the past decades. Now, we are witnessing a transition from simulations of simpler membrane models to multicomponent systems, culminating in realistic models of an increasing variety of cell types and organelles. Here, we review the state of the art in the field of realistic membrane simulations and discuss the current limitations and challenges ahead.

Indexed as

Models, BiologicalCell MembraneHumansLipid BilayersMembrane LipidsMembrane ProteinsMolecular Dynamics SimulationLipid BilayersMembrane LipidsMembrane Proteins

Identifiers

PMID30623647
PMCPMC6509646

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.