Evidence map›Paper›PMID 30624993›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Evidence for a Causal Role of the SH2B3-β

Joshua A Keefe, Shih-Jen Hwang, Tianxiao Huan, Michael Mendelson, Chen Yao, Paul Courchesne, Mohamed A Saleh, Meena S Madhur, Daniel Levy

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Urinary βJournal of xenobiotics · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joshua A KeefeFrom the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).
Shih-Jen HwangFrom the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).
Tianxiao HuanFrom the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).
Michael MendelsonFrom the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).
Chen YaoFrom the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).
Paul CourchesneFrom the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).
Mohamed A SalehDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.A.S., M.S.M.).
Meena S MadhurDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.A.S., M.S.M.).
Daniel LevyFrom the Framingham Heart Study, MA (J.A.K., S.-J.H., T.H., M.M., C.Y., P.C., D.L.).

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Immunophenotyping of Human Hypertension Using Single Cell Multiplex Mass Cytometry to Identify Novel Therapeutic TargetsDP2HL137166 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MADHUR, MEENAKSHI SWAMINATHAN · 2016 to 2021
$2.8M
Framingham Project/LevyZ01HL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2008 to 2008
$1.1M
Diverse Roles of Interleukin 17 Isoforms in the Pathogenesis of HypertensionK08HL121671 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MADHUR, MEENAKSHI SWAMINATHAN · 2014 to 2018
$723k
Circulating Epigenetic Biomarkers for Personalized Cardiovascular Disease PreventionK99HL136875 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI MENDELSON, MICHAEL MAXWELL · 2017 to 2018
$330k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
Intramural NIH HHS Z01 HL006001Intramural NIH HHS Z99 HL999999NHLBI NIH HHS DP2 HL137166NHLBI NIH HHS K08 HL121671NHLBI NIH HHS K99 HL136875NHLBI NIH HHS N01 HC025195
6 · The paper itself

Abstract

Genetic variants at SH2B3 are associated with blood pressure and circulating β

Indexed as

Adaptor Proteins, Signal TransducingAdultAnimalsbeta 2-MicroglobulinBlood PressureCross-Sectional StudiesFemaleHumansHypertensionIntracellular Signaling Peptides and ProteinsMaleMendelian Randomization AnalysisMiceMice, Inbred C57BLMiddle AgedProteinsAdaptor Proteins, Signal Transducingbeta 2-MicroglobulinIntracellular Signaling Peptides and ProteinsProteinsSH2B3 protein, humanbiomarkersepidemiologygene expressiongenome-wide association studyhypertension

Identifiers

PMID30624993
PMCPMC6334659

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.