Evidence map›Paper›PMID 30628201›Full record

ArticleJournal of cellular and molecular medicine2019

Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling.

Wei Xu, Ruijun Xu, Zhikun Li, Yi Wang, Ruixi Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Review
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  18. Mesenchymal stem cells and their microenvironment.Stem cell research & therapy · 2022
    Review
  19. Chronic wounds.Nature reviews. Disease primers · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei XuDepartment of Orthopedic Surgery, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.ORCID 0000-0003-3133-6618
Ruijun XuDepartment of Orthopedic Surgery, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Zhikun LiDepartment of Orthopedic Surgery, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Yi WangDepartment of Orthopedic Surgery, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Ruixi HuDepartment of Orthopedic Surgery, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have drawn great attention because of their therapeutic potential. It has been suggested that intra-venous infused MSCs could migrate the site of injury to help repair the damaged tissue. However, the mechanism for MSC migration is still not clear so far. In this study, we reported that hypoxia increased chemotaxis migration of MSCs. At 4 and 6 hours after culturing in hypoxic (1% oxygen) conditions, the number of migrated MSCs was significantly increased. Meanwhile, hypoxia also increased the expression of HIF-1α and SDF-1. Using small interference RNA, we knocked down the expression of HIF-1α in MSCs to study the role of HIF-1α in hypoxia induced migration. Our data indicated that knocking down the expression of HIF-1α not only abolished the migration of MSCs, but also reduced the expression of SDF-1. Combining the results of migration assay and expression at RNA and protein level, we demonstrated a novel mechanism that controls the increase of MSCs migration. This mechanism involved HIF-1α mediated SDF-1 expression. These findings provide new insight into the role of HIF-1α in the hypoxia induced MSC migration and can be a benefit for the development of MSC-based therapeutics for wound healing.

Indexed as

AnimalsCell HypoxiaCell MovementCell ProliferationCells, CulturedCell SurvivalChemotaxisHypoxia-Inducible Factor 1, alpha SubunitMaleMesenchymal Stem CellsMiceMice, Inbred BALB CMice, Inbred C57BLSignal TransductionHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitchemotaxisHIF-1α signallinghypoxiamesenchymal stem cells

Identifiers

PMID30628201
PMCPMC6378219
OpenAlexW2909736972

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.