Evidence map›Paper›PMID 30628890›Full record

ArticleeLife2019

The novel lncRNA

Cheen Euong Ang, Qing Ma, Orly L Wapinski, ShengHua Fan, Ryan A Flynn, Qian Yi Lee, Bradley Coe, Masahiro Onoguchi, Victor Hipolito Olmos, Brian T Do and 12 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Transcriptomic Convergence and the Female Protective Effect in Autism.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Neurodevelopmental Disorder Caused by Deletion ofThe New England journal of medicine · 2024
    Article
  12. Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Review
  18. Review
  19. RNA-Chrom: a manually curated analytical database of RNA-chromatin interactome.Database : the journal of biological databases and curation · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 3 countries.

Cheen Euong Ang *Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, United States.ORCID 0000-0002-9050-6122
Qing Ma *Center for Personal Dynamic Regulomes, Stanford University, Stanford, United States.ORCID 0000-0001-6812-0584
Orly L Wapinski *Center for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
ShengHua FanJC Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, United States.
Ryan A FlynnCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Qian Yi LeeDepartment of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, United States.ORCID 0000-0001-9200-0910
Bradley CoeDepartment of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, United States.
Masahiro OnoguchiCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Victor Hipolito OlmosDepartment of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, United States.
Brian T DoCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Lynn Dukes-RimskyJC Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, United States.
Jin XuCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.ORCID 0000-0003-0944-9835
Koji TanabeDepartment of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, United States.
LiangJiang WangDepartment of Genetics and Biochemistry, Clemson University, Clemson, United States.
Ulrich EllingInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter, Vienna, Austria.
Josef M PenningerInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter, Vienna, Austria.ORCID 0000-0002-8194-3777
Yang ZhaoCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Kun QuCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Evan E EichlerDepartment of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, United States.ORCID 0000-0002-8246-4014
Anand Srivastava *JC Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, United States.
Marius Wernig *Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, United States.
Howard Y Chang *Center for Personal Dynamic Regulomes, Stanford University, Stanford, United States.ORCID 0000-0002-9459-4393
Dynamic Systems (United States) · USStanford University · USGreenwood Genetic Center · USInstitute of Molecular Biotechnology · ATHoward Hughes Medical Institute · USClemson University · US

Funding

Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI GURALNICK, MICHAEL J · 2014 to 2019
$7.9M
CLONING GENES THAT CAUSE MENTAL RETARDATIONR01HD039331 · NICHD · GREENWOOD GENETIC CENTER · PI SRIVASTAVA, ANAND K · 2000 to 2014
$4.3M
Dissecting the mechanism of direct neural induction through genomic interrogationRC4NS073015 · NINDS · STANFORD UNIVERSITY · PI CHANG, HOWARD Y, QUAKE, STEPHEN R · 2010 to 2010
$2.9M
Howard Hughes Medical Institute Faculty ScholarNHGRI NIH HHS P50 HG007735NICHD NIH HHS R01 HD039331NICHD NIH HHS U54 HD083091NIH Office of the Director P50-HG007735NIH Office of the Director RC4-NS073015NIH Office of the Director RO1-HD39331NINDS NIH HHS RC4 NS073015
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions but are often ignored in human genetics. Combining differential lncRNA expression during neuronal lineage induction with copy number variation morbidity maps of a cohort of children with autism spectrum disorder/intellectual disability versus healthy controls revealed focal genomic mutations affecting several lncRNA candidate loci. Here we find that a t(5:12) chromosomal translocation in a family manifesting neurodevelopmental symptoms disrupts specifically

Indexed as

MutationAutism Spectrum DisorderCell DifferentiationChildChromosomes, Human, Pair 12Chromosomes, Human, Pair 5DNA Copy Number VariationsFemaleGene Expression ProfilingHumansMaleNeurodevelopmental DisordersNeurogenesisNeuronsPedigreeRNA, Long NoncodingRNA, Long Noncodingautismgeneticsgenomicshumaninduced neuronal cellslong non-coding RNAmouseregenerative medicinestem cells

Identifiers

PMID30628890
PMCPMC6380841
OpenAlexW2949983105

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.